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The drug residues of regulatory interest in milk include\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010lactams, sulfonamides, tetracyclines, fluoroquinolones, and macrolides. Milk samples were extracted with acetonitrile and the samples were then subjected to a clean\u2010up procedure using a bonded solid\u2010phase extraction cartridge and a molecular weight cut\u2010off filter. Liquid chromatography\/tandem mass spectrometry (LC\/MS\/MS) triple quadrupole electrospray methods were developed to monitor for the drugs in milk. Since established tolerance levels are set for most of these drugs in milk, the initial screening procedure was semi\u2010quantitative, where samples were compared to the response of a positive control. The positive control, consisting of an extract from a portion of milk fortified with the drugs at half their allowed levels, was used to set the laboratory's minimum response criteria for unknown samples. Confirmatory analyses, with additional ion transitions for each residue, were performed on the same extracts. Published in 2008 by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.3532","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T08:16:21Z","timestamp":1208247381000},"page":"1467-1480","source":"Crossref","is-referenced-by-count":91,"title":["Multi\u2010class, multi\u2010residue liquid chromatography\/tandem mass spectrometry screening and confirmation methods for drug residues in milk"],"prefix":"10.1002","volume":"22","author":[{"given":"Sherri B.","family":"Turnipseed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy C.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Karbiwnyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Madson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/88.2.595"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2005.04.007"},{"key":"e_1_2_5_4_2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010006\u20100586\u2010z"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.02.038"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf040185j"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0605502"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.12.014"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2005.05.001"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2635"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70.54"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2116\/bunsekikagaku.56.317"},{"key":"e_1_2_5_14_2","unstructured":"SmithS GiesekerC ReimschuesselR CarsonMC.Multiclass confirmation of veterinary drug residues in fish by liquid chromatography\u2010ion trap mass spectrometry. FDA Science Forum April 27\u201328 2005; Washington DC."},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chromb.2007.07.011"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.03.025"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.11.099"},{"key":"e_1_2_5_18_2","unstructured":"DelepineB MoretainJP.Antibiotic residues in milk: LC\u2010MS\u2010MS confirmation (identification and quantification) of positive results obtained with microbial inhibitor screening tests. In Proceedings of the Euroresidue V Conference Van Ginkel LA (ed). Noordwijkerhout The Netherlands May 10\u201312 2004;2004;165\u2013171."},{"key":"e_1_2_5_19_2","unstructured":"GagnonL FortierS.Simple extraction method for quantitative analysis of 45 antibiotics in milk. 121st AOAC Annual Meeting & Exposition September 16\u201320 2007 Anaheim CA."},{"key":"e_1_2_5_20_2","unstructured":"US FDA.National Milk Drug Residue Data Base. Food and Drug Administration Center for Food Safety and Nutrition 2004. Available:http:\/\/www.cfsan.fda.gov\/\u223cear\/milkrp03.html. Accessed on 11\/08\/2007."},{"key":"e_1_2_5_21_2","unstructured":"US FDA.Tolerance and\/or Safe Levels of Animal Drug Residues in Milk; 2005 September 27 2005. Available:http:\/\/www.cfsan.fda.gov\/\u223cear\/mi\u201005\u20105.html. Accessed on 11\/08\/2007."},{"key":"e_1_2_5_22_2","unstructured":"US FDA.Mass Spectrometry for Confirmation of the Identity of Animal Drug Residues 2003 Center for Veterinary Medicine Guidance for Industry #118. Availablehttp:\/\/www.fda.gov\/cvm\/guidance\/guide118.pdf. Accessed on 11\/08\/2007."},{"key":"e_1_2_5_23_2","unstructured":"US FDA.Guideline for Approval of a Method of Analysis for Residues;2005 Available:http:\/\/www.fda.gov\/cvm\/Guidance\/1731.htm. 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