{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:15:53Z","timestamp":1790957753078,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T00:00:00Z","timestamp":1219104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2008,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The electrospray ionization (ESI) ion trap and quadrupole time\u2010of\u2010flight (QqToF) mass spectra of heroin and seven related alkaloids, i.e., morphine, codeine,\n                    <jats:italic>O<\/jats:italic>\n                    \u20106\u2010monoacetylmorphine (6\u2010MAM), thebaine, acetylcodeine, papaverine and narcotine, have been extensively investigated in this work. The ESI mass spectrometric fragmentation pathways of protonated 6\u2010MAM, heroin, acetylcodeine, and thebaine were comprehensively elucidated for the first time with the aid of high\u2010resolution mass spectrometry. It was found that cleavage of the piperidine ring was the featured fragmentation route of six of the compounds, although not of papaverine and narcotine. In addition, a simple high\u2010performance liquid chromatography (HPLC)\u2010based separation method gave baseline resolution of all eight components. This study could play an important role in the screening for these alkaloids in different matrices by HPLC coupled to tandem mass spectrometry (MS\/MS). Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.3686","type":"journal-article","created":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T04:57:18Z","timestamp":1219121838000},"page":"2851-2862","source":"Crossref","is-referenced-by-count":38,"title":["Fragmentation pathways of heroin\u2010related alkaloids revealed by ion trap and quadrupole time\u2010of\u2010flight tandem mass spectrometry"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhengxiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.01.062"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.12.005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02258915"},{"key":"e_1_2_6_5_2","first-page":"121","volume":"59","author":"Neumann H","year":"1992","journal-title":"Toxichem. 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