{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:15:12Z","timestamp":1778674512129,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2001,7,16]],"date-time":"2001-07-16T00:00:00Z","timestamp":995241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2001,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A method based on liquid chromatography\/mass spectrometry with an electrospray ion source and a single quadrupole instrument (LC\/ES\u2010MS) has been developed for determining trace levels of eight widely used penicillins in aqueous environmental samples. Analyte extraction was performed from 4 L tap water, 2 L groundwater, 1 L river water, 0.2 L treated sewage and 0.1 L raw sewage, by using a Carbograph 4 cartridge. During removal of the solvent, penicillins were purposely allowed to convert into their penicilloyl methyl esters. This \u2018in situ\u2019 derivatization step resulted in a dramatic enhancement of the response of the ES\u2010MS system for non\u2010amphoteric penicillins. Analyte recoveries were better than 80% irrespective of the type of aqueous sample, with the exception of amoxicillin (76%) and ampicillin (77%) in tap water. At the level of 50\u2005ng\/L of each analyte in ground water, the within\u2010day precision was in the range 6\u201310%. Calibration curves were linear for injected amounts up to 800\u2005ng, with R\n                    <jats:sup>2<\/jats:sup>\n                    in the range 0.9952\u20130.9995. When injecting large equivalent volumes of the aqueous samples, the electrospray matrix effect altered in\u2010source collision\u2010induced dissociation (CID) spectra of the analytes by severely weakening signals for fragment ions, as compared to spectra of reference standards. Remedies to obviate this anomalous unwelcome effect are suggested. On the basis of a signal\u2010to\u2010noise ratio of 10, limits of quantification were estimated to range between 2 (cloxacillin) and 24\u2005ng\/L (amoxicillin) in river water. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.381","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:44:49Z","timestamp":1030293889000},"page":"1391-1400","source":"Crossref","is-referenced-by-count":37,"title":["Method development for measuring trace levels of penicillins in aqueous environmental samples"],"prefix":"10.1002","volume":"15","author":[{"given":"Federica","family":"Bruno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Curini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Di","family":"Corcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Nazzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Samperi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,16]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"57","volume":"83","author":"Stan H\u2010J","year":"1992","journal-title":"Vom Wasser"},{"key":"e_1_2_4_3_2","first-page":"997","volume":"21","author":"Holm JV","year":"1995","journal-title":"Environ. 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