{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:03:49Z","timestamp":1761512629974,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,5]],"date-time":"2009-01-05T00:00:00Z","timestamp":1231113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2009,2,15]]},"abstract":"Abstract<\/jats:title>\n \n Selected ion flow tube mass spectrometry (SIFT\u2010MS) is a sensitive technique capable of measuring volatile compounds (VCs) in complex gas mixtures in real time; it is now being applied to breath analysis. We investigated the effect of inhalers containing chlorofluorocarbons (CFCs) on the detection and measurement of haloamines in human breath. SIFT\u2010MS mass scans (MS) and selected ion monitoring (SIM) scans were performed on three healthy non\u2010smoking volunteers before and after inhalation of the following medications: Combivent\u2122 metered\u2010dose inhaler (MDI) (CFC\u2010containing); Ventolin\u2122 MDI (CFC\u2010free); Atrovent\u2122 MDI (CFC\u2010free), Beclazone\u2122 MDI (CFC\u2010containing); Duolin\u2122 nebuliser. In addition, the duration of the persistence of the mass\/charge ratios was measured for 20\u2009h. Inhalers containing CFCs generated large peaks at\n m\/z<\/jats:italic>\n 85, 87, 101, 103 and 105\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n , consistent with the predicted product ions of CFCs 12, 114 and 11. No such peaks were seen with Duolin\u2122 via nebuliser, or CFC\u2010free MDIs. We conclude that measurement of VCs, such as haloamines, with product ions of similar\n m\/z<\/jats:italic>\n values to the ions found for CFCs would be significantly affected by the presence of CFCs in inhalers. This issue needs to be accounted for prior to the measurement of VCs in breath in people using inhalers containing CFCs. Copyright \u00a9 2009 John Wiley & Sons, Ltd.\n <\/jats:p>","DOI":"10.1002\/rcm.3875","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T14:30:12Z","timestamp":1231511412000},"page":"443-447","source":"Crossref","is-referenced-by-count":3,"title":["Interference of chlorofluorocarbon (CFC)\u2010containing inhalers with measurements of volatile compounds using selected ion flow tube mass spectrometry"],"prefix":"10.1002","volume":"23","author":[{"given":"Michael J.","family":"Epton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Ledingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Dummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan\u2010Ping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bronwen","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senti T.","family":"Senthilmohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Scotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall","family":"Allardyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen P.","family":"Swanney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3418"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.244"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1176(86)87041-0"},{"key":"e_1_2_7_5_2","unstructured":"United Nations Environment Programme. Technology and Economics Assessment Montreal protocol on substances that deplete the ozone layer. 1996: United Nations Environment Programme."},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh154"},{"key":"e_1_2_7_7_2","first-page":"481","volume":"6","author":"Chiou WL","year":"1973","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/60.1.20"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.3875","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.3875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:07:57Z","timestamp":1761491277000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.3875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,5]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2,15]]}},"alternative-id":["10.1002\/rcm.3875"],"URL":"https:\/\/doi.org\/10.1002\/rcm.3875","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"type":"print","value":"0951-4198"},{"type":"electronic","value":"1097-0231"}],"subject":[],"published":{"date-parts":[[2009,1,5]]}}}