{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:59:08Z","timestamp":1762430348731,"version":"build-2065373602"},"reference-count":75,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T00:00:00Z","timestamp":1232582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2009,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We have developed a technique combining acid hydrolysis with matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight mass spectrometry (MALDI\u2010TOF MS) for the rapid study of the changes in the levels of positive and negative acute phase protein biomarkers in the sera of patients suffering from major depression. The serum proteins were first precipitated using an organic solvent; after separation, they were subjected to hydrochloric acid hydrolysis (6\u2009M HCl) for 10\u2009min. The resulting peptides were characterized using MALDI\u2010TOF MS. Short\u2010term treatment of the serum proteins with HCl efficiently removed interference from the abundant protein \u2013 albumin \u2013 and produced abundant peptide ion signals in the range of\n                    <jats:italic>m<\/jats:italic>\n                    \/\n                    <jats:italic>z<\/jats:italic>\n                    4000\u201310\u2009000. This approach allowed us to rapidly detect the peptide ions originating from transferrin (a common negative acute phase protein) and fibrinogen (a common positive acute phase protein). The average ratios and (standard deviations) of the ion signals derived from transferrin\/fibrinogen were 3.58 (\u00b11.93) for the healthy control subjects and 1.02 (\u00b10.52) for the patients suffering from major depression. The differences in transferrin\/fibrinogen ratios between healthy controls and patients suggest that major depression will induce internal inflammation and cause either an increase in the level of fibrinogen or a decrease in the level of transferrin. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.3908","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T05:49:11Z","timestamp":1232603351000},"page":"589-598","source":"Crossref","is-referenced-by-count":23,"title":["Acid hydrolysis followed by matrix\u2010assisted laser desorption\/ionization mass spectrometry for the rapid diagnosis of serum protein biomarkers in patients with major depression"],"prefix":"10.1002","volume":"23","author":[{"given":"Li\u2010Hua","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiao\u2010Lai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jentaie","family":"Shiea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(94)00101-M"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700032712"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(92)90066-F"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)94464-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(96)84035-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0924-977X(95)90428-G"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(96)02783-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10869"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.10.009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.09.043"},{"key":"e_1_2_6_12_2","first-page":"325","volume":"29","author":"Chen CC","year":"2006","journal-title":"J. Chang. Gung. Med."},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.11.005"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2004.01235.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(03)00071-4"},{"key":"e_1_2_6_16_2","first-page":"749","volume":"15","author":"Bruno A","year":"1969","journal-title":"J. Riv. Neurobiol."},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/070674376601101S14","author":"Rosenblatt S","year":"1966","journal-title":"J. Can. Psychiatr. Assoc."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00049-7"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(82)90023-3"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(97)00046-2"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1997.tb09622.x"},{"key":"e_1_2_6_22_2","first-page":"7","volume":"4","author":"Sen S","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.05.007"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41496-8"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00281458"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5421"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9888(199801)33:1<1::AID-JMS624>3.0.CO;2-9"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.11501601299"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.437"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200390057"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.11501301150"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.11501401183"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.11501601190"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00012-2"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M200066-MCP200"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr049761h"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1290020802"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1290080811"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00291a042"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00171a028"},{"key":"e_1_2_6_41_2","first-page":"181","volume":"24","author":"Overberg A","year":"1992","journal-title":"Mass Spectrom. Biol. Sci."},{"key":"e_1_2_6_42_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00216-006-0905-4","volume":"387","author":"Chensong P","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(19980515)12:9<529::AID-RCM188>3.0.CO;2-E"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3217"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.06.013"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.R200007-MCP200"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.069252"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac010619z"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2004.12.017"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1011"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac051521d"},{"volume-title":"Structured Clinical Interview for DSM\u2010IV Axis II Personality Disorders (SCID\u2010II)","year":"1997","author":"First MB","key":"e_1_2_6_52_2"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1039\/b418288j"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.876"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60640-3"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.8.2504"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.6.1616"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61437-7"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.4.1731"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145704004936"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(96)02915-0"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01490506"},{"key":"e_1_2_6_63_2","first-page":"785","volume":"19","author":"Razeghi E","year":"2008","journal-title":"Saudi J. Kidney Dis. Transpl."},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500093"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(91)90272-Z"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.04.023"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.07.002"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00157-9"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(96)00037-0"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-003-0356-6"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)31130-5"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(97)00180-8"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(97)00139-6"},{"key":"e_1_2_6_74_2","first-page":"534","volume":"41","author":"Seidel A","year":"1995","journal-title":"J. Immunol."},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90065-8"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M400188-MCP200"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.3908","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.3908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:22:26Z","timestamp":1761488546000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.3908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,22]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,3,15]]}},"alternative-id":["10.1002\/rcm.3908"],"URL":"https:\/\/doi.org\/10.1002\/rcm.3908","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"type":"print","value":"0951-4198"},{"type":"electronic","value":"1097-0231"}],"subject":[],"published":{"date-parts":[[2009,1,22]]}}}