{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:50:41Z","timestamp":1761929441561,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T00:00:00Z","timestamp":1242864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Scientific and Technical Foundation of Zhejiang"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2009,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ginkgolic acids have been shown to possess allergenic as well as genotoxic and cytotoxic properties. The question arises whether the metabolism of ginkgolic acids in the liver could decrease or increase their toxicity. In this study, the\n                    <jats:italic>in<\/jats:italic>\n                    <jats:italic>vitro<\/jats:italic>\n                    metabolism of ginkgolic acid (15:1, GA), one component of ginkgo acids, was investigated as a model compound in Sprague\u2010Dawley rat liver microsomes. The metabolites were analyzed by ultra\u2010performance liquid chromatography coupled with photodiode array detector\/negative\u2010ion electrospray ionization tandem mass spectrometry (UPLC\u2010PDA\/ESI\u2010MS\/MS) and hydrogen\/deuterium (H\/D) exchange. The result showed that the benzene ring remained unchanged and the oxidations occurred at the side alkyl chain in rat liver microsomes. At least eight metabolites were found. Among them, six phase I metabolites were tentatively identified. This study might be useful for the investigation of toxicological mechanism of ginkgolic acids. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.4086","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T07:04:30Z","timestamp":1242889470000},"page":"1899-1906","source":"Crossref","is-referenced-by-count":16,"title":["Structural elucidation of metabolites of ginkgolic acid in rat liver microsomes by ultra\u2010performance liquid chromatography\/electrospray ionization tandem mass spectrometry and hydrogen\/deuterium exchange"],"prefix":"10.1002","volume":"23","author":[{"given":"Z. H.","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. S.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. D.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. W.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(98)90016-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00022"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01194-3"},{"key":"e_1_2_6_5_2","first-page":"555","volume":"37","author":"Yang LQ","year":"2002","journal-title":"Acta. Pharm. Sin."},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2589"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3070"},{"key":"e_1_2_6_8_2","first-page":"909","volume":"38","author":"Yang LQ","year":"2003","journal-title":"Chin. Pharm. J."},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-4899-6844-9","volume-title":"Introduction to Drug Metabolism","author":"Gibson GG","year":"1994"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2003.08.001"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00078a017"},{"volume-title":"Interpretation of Mass Spectra","year":"1993","author":"McLafferty FW","key":"e_1_2_6_13_2"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1545"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac961030g"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0725-5"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011761200"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0026-895X(25)12526-1","volume":"19","author":"Gozukara EM","year":"1981","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(88)90197-2"},{"key":"e_1_2_6_20_2","first-page":"1","volume-title":"Biochemical Pharmacology and Toxicology","author":"Wixtrom RN","year":"1985"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.4086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.4086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.4086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T11:33:26Z","timestamp":1761478406000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.4086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,21]]},"references-count":19,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2009,7,15]]}},"alternative-id":["10.1002\/rcm.4086"],"URL":"https:\/\/doi.org\/10.1002\/rcm.4086","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"type":"print","value":"0951-4198"},{"type":"electronic","value":"1097-0231"}],"subject":[],"published":{"date-parts":[[2009,5,21]]}}}