{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:04:36Z","timestamp":1790939076078,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2010,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Signal suppression is a common issue when analyzing compounds by liquid chromatography coupled to mass spectrometry (LC\/MS\/MS). Suppression of signals is caused by co\u2010eluting matrix compounds and is thought to take place in the interface. This paper reports strong signal suppression effects which were observed when using a single\u2010stage Orbitrap instrument which was coupled by an electrospray interface to a liquid chromatograph. This type of signal suppression (often the complete loss of certain analyte signal) is observed in addition to signal suppression originating in the electrospray interface. The location of where this phenomenon occurs was shown to be clearly beyond the interface region. It was suspected that not the Orbitrap cell itself, but the C\u2010trap, which is an integral part within the Orbitrap instrument, was the probable location. Such post\u2010interface signal suppression was observed \u2013 and could be experimentally induced \u2013 when multiply charged ions (e.g. electrospray protonated proteins) were co\u2010eluting with the analytes. High concentrations of proteins, yet not exceeding the maximum ion capacity of the trap, can cause a complete loss of all low\n                    <jats:italic>m\/z<\/jats:italic>\n                    masses. This paper describes the practical implication when analyzing heavy matrix samples and discusses strategies to reduce such detrimental effects. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.4615","type":"journal-article","created":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T23:38:11Z","timestamp":1276731491000},"page":"2162-2170","source":"Crossref","is-referenced-by-count":58,"title":["Post\u2010interface signal suppression, a phenomenon observed in a single\u2010stage Orbitrap mass spectrometer coupled to an electrospray interfaced liquid chromatograph"],"prefix":"10.1002","volume":"24","author":[{"given":"A.","family":"Kaufmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Widmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Maden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,16]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"364","author":"Vanhaecke L","year":"2009","journal-title":"LC\u2010GC Eur."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2008.11.002"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.03.089"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac8018312"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20097"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.12.030"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0514624"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jms.856"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2006.03.006"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20186"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0518811"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2009.03.002"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2009.03.024"},{"key":"e_1_2_5_15_2","unstructured":"Swiss Food Manual SOP 1570.1 2006."},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3904"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.4615","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.4615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.4615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:45:04Z","timestamp":1761489904000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.4615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,16]]},"references-count":15,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,7,30]]}},"alternative-id":["10.1002\/rcm.4615"],"URL":"https:\/\/doi.org\/10.1002\/rcm.4615","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,16]]}}}