{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:58:34Z","timestamp":1787507914431,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T00:00:00Z","timestamp":1300060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BBSRC, EPSRC, Scottish Funding Council"},{"name":"Universities of Glasgow and Edinburgh"},{"name":"Melinda Gates Foundation, Global Health Grant","award":["OPPPGH5337"],"award-info":[{"award-number":["OPPPGH5337"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2011,4,15]]},"abstract":"<jats:p>Mass spectrometry imaging (MSI) is a powerful tool in metabolomics and proteomics for the spatial localization and identification of pharmaceuticals, metabolites, lipids, peptides and proteins in biological tissues. However, sample preparation remains a crucial variable in obtaining the most accurate distributions. Common washing steps used to remove salts, and solvent\u2010based matrix application, allow analyte spreading to occur. Solvent\u2010free matrix applications can reduce this risk, but increase the possibility of ionisation bias due to matrix adhesion to tissue sections. We report here the use of matrix\u2010free MSI using laser desorption ionisation performed on a 12 T Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. We used unprocessed tissue with no post\u2010processing following thaw\u2010mounting on matrix\u2010assisted laser desorption ionisation (MALDI) indium\u2010tin oxide (ITO) target plates. The identification and distribution of a range of phospholipids in mouse brain and kidney sections are presented and compared with previously published MALDI time\u2010of\u2010flight (TOF) MSI distributions. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rcm.4939","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T10:15:36Z","timestamp":1300356936000},"page":"969-972","source":"Crossref","is-referenced-by-count":27,"title":["Matrix\u2010free mass spectrometric imaging using laser desorption ionisation\n                    <scp>F<\/scp>\n                    ourier transform ion cyclotron resonance mass spectrometry"],"prefix":"10.1002","volume":"25","author":[{"given":"Richard J. A.","family":"Goodwin","sequence":"first","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Pitt","sequence":"additional","affiliation":[{"name":"School of Life &amp; Health Sciences Aston University  Birmingham B4 7ET UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Harrison","sequence":"additional","affiliation":[{"name":"Breakthrough Research Unit and Division of Pathology, Institute of Genetics and Molecular Medicine University of Edinburgh  Edinburgh EH4 2XR UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K.","family":"Weidt","sequence":"additional","affiliation":[{"name":"SIRCAMS, School of Chemistry University of Edinburgh  Edinburgh EH9 3JJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat R. R.","family":"Langridge\u2010Smith","sequence":"additional","affiliation":[{"name":"SIRCAMS, School of Chemistry University of Edinburgh  Edinburgh EH9 3JJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Logan Mackay","sequence":"additional","affiliation":[{"name":"SIRCAMS, School of Chemistry University of Edinburgh  Edinburgh EH9 3JJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac970888i"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac990781q"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr060346u"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20124"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800320"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.09.180"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac051534r"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac070958d"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.505"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac060974v"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2008.02.013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4567"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac100398y"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2009.04012.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac100661h"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800201"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.4939","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.4939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.4939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcm.4939","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.4939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:33:08Z","timestamp":1761492788000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.4939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,14]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,4,15]]}},"alternative-id":["10.1002\/rcm.4939"],"URL":"https:\/\/doi.org\/10.1002\/rcm.4939","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,14]]}}}