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The EESI apparatus was then tested with a variety of small, organic molecules to assess sensitivity, linearity and dynamic range. The performance of the technique will depend on the mass spectrometer used for the experiments; in the configurations used here it has a useable dynamic range of around 3.5 orders of magnitude with a linear range of around 2.5 orders of magnitude and is capable of analysing species present down to low \u00b5g\/mL with signal\u2010to\u2010noise ratio greater than 2.5. The use of EESI for reaction monitoring was validated using a series of mock reaction mixtures and then used to monitor the base hydrolysis of ethyl salicylate to salicylic acid. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rcm.5016","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T22:57:21Z","timestamp":1303167441000},"page":"1445-1451","source":"Crossref","is-referenced-by-count":37,"title":["On\u2010line reaction monitoring by extractive electrospray ionisation"],"prefix":"10.1002","volume":"25","author":[{"given":"Bryan J.","family":"McCullough","sequence":"first","affiliation":[{"name":"LGC  Queens Road Teddington TW11 0LY UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Bristow","sequence":"additional","affiliation":[{"name":"AstraZeneca Pharmaceutical Development  Silk Road Business Park, Charter Way Macclesfield SK10 2NA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"O'Connor","sequence":"additional","affiliation":[{"name":"LGC  Queens Road Teddington TW11 0LY UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Hopley","sequence":"additional","affiliation":[{"name":"LGC  Queens Road Teddington TW11 0LY UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-7439(99)00025-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/b005038p"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/op020075i"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/op7000854"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9888(199601)31:1<1::AID-JMS295>3.0.CO;2-J"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2005.03.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie9707984"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1255\/ejms.837"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201004861"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104404"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac050162j"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac051470k"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/b602614a"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2006.08.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac070109q"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac701960q"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac070443m"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac102765z"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4556"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3700"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9019494"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1282"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac061843x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3584"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/b821497b"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac101283x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.11.088"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac802440w"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.5016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.5016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T12:42:18Z","timestamp":1761482538000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.5016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,18]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,5,30]]}},"alternative-id":["10.1002\/rcm.5016"],"URL":"https:\/\/doi.org\/10.1002\/rcm.5016","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,18]]}}}