{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:30:48Z","timestamp":1790764248293,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:00:00Z","timestamp":1342483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:sec>\n                    <jats:title>RATIONALE<\/jats:title>\n                    <jats:p>A recently developed miniature electrospray ionisation mass spectrometer has been coupled to a preparative flow chemistry system in order to monitor reactive intermediates and competing reaction paths, screen starting materials, and optimise reaction conditions. Although ideally suited to the application, mass spectrometers have rarely been used in this way, as traditional instruments are too bulky to be conveniently coupled to flow chemistry platforms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A six\u2010port switching valve fitted with a 5\u2009\u03bcL loop was used to periodically sample the flow stream leaving the reactor coil. Mass spectra corresponding to the sample loop contents were observed approximately 10\u2009s after activating the valve. High fluidic pressure was maintained throughout to ensure that gaseous products remained in solution. As an illustrative example of how this apparatus can be employed, the generation of benzyne and its subsequent reaction with furan were investigated. Benzyne was prepared via diazotisation of anthranilic acid using\n                      <jats:italic>tert<\/jats:italic>\n                      \u2010butyl nitrite.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Unexpectedly, the explosive diazotised intermediate was detected by the mass spectrometer at low coil temperatures or short residence times. The optimum reactor temperature and residence time for production of the desired Diels\u2010Alder product are 50\u2009\u00b0C and 3\u20135\u2009min, respectively. There are competing reaction pathways leading to the formation of acridone and several other by\u2010products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>On\u2010line mass spectrometry allowed the flow conditions to be quickly tuned for safe operation and optimal generation of the desired product. The validity of this approach was corroborated by off\u2010line liquid chromatography\/mass spectrometry (LC\/MS) analysis of flow samples. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.6312","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T09:08:56Z","timestamp":1342775336000},"page":"1999-2010","source":"Crossref","is-referenced-by-count":127,"title":["Continuous flow reaction monitoring using an on\u2010line miniature mass spectrometer"],"prefix":"10.1002","volume":"26","author":[{"given":"Duncan L.","family":"Browne","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Wright","sequence":"additional","affiliation":[{"name":"Microsaic Systems plc  GMS House, Boundary Road Woking GU21 5BX UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Deadman","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Dunnage","sequence":"additional","affiliation":[{"name":"Microsaic Systems plc  GMS House, Boundary Road Woking GU21 5BX UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Baxendale","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven V.","family":"Ley","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"84","volume-title":"Microreactors in Organic Synthesis and Catalysis","author":"Baxendale I. 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