{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:08:46Z","timestamp":1768464526501,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2012,12,30]]},"abstract":"<jats:sec>\n                    <jats:title>RATIONALE<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Swertia punicea<\/jats:italic>\n                      Hemsl. (Gentianaceae) are used mainly for the treatment of acute bilious hepatitis, cholecystitis, fever, intoxification and jaundice in China, as a traditional Chinese folk medicine. Xanthones as the main chemical components of\n                      <jats:italic>Swertia punicea<\/jats:italic>\n                      have many possible pharmacological properties, such as hepatoprotective and anti\u2010HIV. In order to obtain an overall picture of the xanthones of\n                      <jats:italic>Swertia punicea<\/jats:italic>\n                      , high\u2010performance liquid chromatography diode\u2010array detection\/tandem mass spectrometry (HPLC\/DAD\u2010ESI\u2010MS\n                      <jats:sup>n<\/jats:sup>\n                      ) was applied to the structural characterization of xanthones in ethyl acetate and acetone extracts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The ESI\u2010MS fragmentation behaviors of xanthones were investigated based on the 17 reference xanthones and then applied to the structural characterization of xanthones in ethyl acetate and acetone extracts of\n                      <jats:italic>Swertia punicea<\/jats:italic>\n                      by HPLC\/DAD\u2010ESI\u2010MS\n                      <jats:sup>n<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The fragmentation rules of aglycone,\n                      <jats:italic>C<\/jats:italic>\n                      \u2010glycosides,\n                      <jats:italic>O<\/jats:italic>\n                      \u2010glycosides, and polyxanthones with different linkages were summarized. The observed fragmentation pathways were used successfully for the analysis of the xanthone constituents of\n                      <jats:italic>Swertia punicea<\/jats:italic>\n                      , and a total of 34 xanthones were identified, among which 16 compounds were new and one compound was reported from this species for the first time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      The described methods were very valuable for the identification of xanthones, especially of the trace compounds, and therefore could be utilized for sensitive and rapid qualitative analysis of xanthones in\n                      <jats:italic>Swertia punicea<\/jats:italic>\n                      . Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.6419","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T22:12:28Z","timestamp":1352326348000},"page":"2913-2923","source":"Crossref","is-referenced-by-count":33,"title":["Identification of xanthones from\n                    <i>Swertia punicea<\/i>\n                    using high\u2010performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry"],"prefix":"10.1002","volume":"26","author":[{"given":"Xin\u2010Gang","family":"Du","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Peking University Health Science Center  Beijing 100191 China"},{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, School of Pharmacy Hunan University of Chinese Medicine  Changsha 410208 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing\u2010Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Peking University Health Science Center  Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Urban Agriculture (North) Ministry of Agriculture Beijing University of Agriculture  Beijing 102206 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharathi","family":"Avula","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences University of Mississippi  University MS 38677 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikhlas A.","family":"Khan","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences University of Mississippi  University MS 38677 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De\u2010An","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,7]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"53","article-title":"Chemical and pharmaceutical aspects of Swertia","volume":"36","author":"Yu F. 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