{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:41:40Z","timestamp":1791225700754,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2013,7,15]]},"abstract":"<jats:sec>\n                    <jats:title>RATIONALE<\/jats:title>\n                    <jats:p>\n                      Procymidone is a dicarboximide fungicide mainly used for vineyard protection but also for different crops. The structural elucidation of by\u2010products arising from the UV\u2010visible photodegradation of procymidone has been investigated by gas chromatography coupled with mass spectrometry. The potential toxicities of photoproducts were estimated by\n                      <jats:italic>in silico<\/jats:italic>\n                      tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Aqueous solutions of procymidone were irradiated for up to 90\u2009min in a self\u2010made reactor equipped with a mercury lamp. Analyses were carried out on a gas chromatograph coupled with an ion trap mass spectrometer operated in electron ionization and methanol positive chemical ionization. Multistage collision\u2010induced dissociation (CID) experiments were performed to establish dissociation pathways of ions. Toxicities of byproducts were estimated using the QSAR T.E.S.T. program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Sixteen photoproducts were investigated. Chemical structures were proposed mainly based on the interpretation of multistage CID experiments, but also on their relative retention times and kinetics data. These structures enabled photodegradation pathways to be suggested. Only three photoproducts remain present after 90\u2009min of irradiation. Among them, 3,5\u2010dichloroaniline presents a predicted rat LD50 toxicity about ten times greater than that of procymidone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>3,5\u2010Dichloroaniline is the only photoproduct reported in previous articles. Eight by\u2010products among the sixteen characterized might be as toxic, if not more, than procymidone itself considering the QSAR\u2010predicted rat LD50. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.6598","type":"journal-article","created":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T06:05:31Z","timestamp":1369461931000},"page":"1505-1516","source":"Crossref","is-referenced-by-count":27,"title":["Ultraviolet degradation of procymidone \u2013 structural characterization by gas chromatography coupled with mass spectrometry and potential toxicity of photoproducts using\n                    <i>in silico<\/i>\n                    tests"],"prefix":"10.1002","volume":"27","author":[{"given":"Ahmad","family":"Rifai","sequence":"first","affiliation":[{"name":"Laboratoire des M\u00e9canismes R\u00e9actionnels UMR\u20107651, Ecole Polytechnique  91128 Palaiseau Cedex France"},{"name":"Laboratoire d'Analyse des Pesticides et des Polluants Organiques \u2010 Commission Libanaise de l'\u00c9nergie Atomique \u2010 Centre National de Recherches Scientifiques \u2010 Beyrouth  Liban"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Souissi","sequence":"additional","affiliation":[{"name":"Laboratoire des M\u00e9canismes R\u00e9actionnels UMR\u20107651, Ecole Polytechnique  91128 Palaiseau Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Genty","sequence":"additional","affiliation":[{"name":"Laboratoire des M\u00e9canismes R\u00e9actionnels UMR\u20107651, Ecole Polytechnique  91128 Palaiseau Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Clavaguera","sequence":"additional","affiliation":[{"name":"Laboratoire des M\u00e9canismes R\u00e9actionnels UMR\u20107651, Ecole Polytechnique  91128 Palaiseau Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Laboratoire des M\u00e9canismes R\u00e9actionnels UMR\u20107651, Ecole Polytechnique  91128 Palaiseau Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farouk","family":"Jaber","sequence":"additional","affiliation":[{"name":"Laboratoire d'Analyse des Pesticides et des Polluants Organiques \u2010 Commission Libanaise de l'\u00c9nergie Atomique \u2010 Centre National de Recherches Scientifiques \u2010 Beyrouth  Liban"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Bouchonnet","sequence":"additional","affiliation":[{"name":"Laboratoire des M\u00e9canismes R\u00e9actionnels UMR\u20107651, Ecole Polytechnique  91128 Palaiseau Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.10.102"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2005.07.009"},{"key":"e_1_2_5_4_1","unstructured":"Journal officiel de l'Union europ\u00e9enne 2010 9 European Commission"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2011.12.016"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.06.011"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2004.10.005"},{"key":"e_1_2_5_8_1","first-page":"4","article-title":"European Union. 3600\/92DE","year":"1992","journal-title":"Official Journal of the European Union"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.03.004"},{"key":"e_1_2_5_10_1","unstructured":"O. o. 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