{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:14:57Z","timestamp":1768644897240,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2014,6,30]]},"abstract":"<jats:sec>\n                    <jats:title>RATIONALE<\/jats:title>\n                    <jats:p>Edible bird's nest (EBN) is a renowned food item in the Chinese community due to the therapeutic effects claimed to be brought about by its consumption. However, very little scientific information has been revealed to support these claims. Thus, metabolite profiling was performed to identify the metabolites and to relate them to the medicinal properties of EBN. The study also aims to further extend the results to determine any possible differences when the EBNs are classified according to their coloration, countries or production sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Extraction of the metabolites was performed via sonication of EBN with methanol and chloroform. Two analytical platforms, namely gas chromatography\/mass spectrometry (GC\/MS) and liquid chromatography\/mass spectrometry (LC\/MS), were utilized to detect the metabolites. This multi\u2010analytical platform would provide a comprehensive coverage of the metabolites in EBN. GC\/MS analysis was conducted in scan mode from\n                      <jats:italic>m\/z<\/jats:italic>\n                      50\u2013650. On the other hand, LC\/MS analysis was operated in both positive and negative ion mode from\n                      <jats:italic>m\/z<\/jats:italic>\n                      150\u20131000.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Metabolites were identified and their relationships with the medicinal properties of EBN were deduced. Classification with chemometrics illustrates that EBNs could be differentiated according to their coloration, countries and production sites. This differentiation was due to the environment where the EBNs are produced. Furthermore, GC\/MS was demonstrated to be more suitable for classification as the processing methods of the EBNs did not cause a significant variation in the metabolites detected by GC\/MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The overall findings suggest that the novel approach of metabolite profiling offers new insights to understanding EBN and provided evidence to support the medicinal properties of EBN. In addition, the success of classification of EBNs with metabolite profiling combining with chemometrics represents a paradigm shift in the quality control of this food item. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.6914","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T03:16:34Z","timestamp":1399259794000},"page":"1387-1400","source":"Crossref","is-referenced-by-count":35,"title":["Metabolite profiling of edible bird's nest using gas chromatography\/mass spectrometry and liquid chromatography\/mass spectrometry"],"prefix":"10.1002","volume":"28","author":[{"given":"Yong Guan","family":"Chua","sequence":"first","affiliation":[{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 11754 Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bosco Chen","family":"Bloodworth","sequence":"additional","affiliation":[{"name":"Food Laboratory, Centre of Analytical Sciences Health Sciences Authority  11 Outram Road Singapore 16907 Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai Peng","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 11754 Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam Fong Yau","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 11754 Singapore"},{"name":"NUS Environmental Research Institute  5A Engineering Drive 1, T\u2010Lab Building Singapore 117411 Singapore"},{"name":"Shenzhen Engineering Laboratory for Eco\u2010efficient Polysilicate Materials, School of Environment and Energy Peking University Shenzhen Graduate School  Shenzhen 518055 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2005.02.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(87)90133-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BIOC.0000047905.79709.7f"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.02.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.100705"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540105.2011.625494"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/797520"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114342"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200109)22:16<3589::AID-ELPS3589>3.0.CO;2-J"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.02002.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000601)86:5<603::AID-IJC1>3.0.CO;2-H"},{"key":"e_1_2_6_13_1","first-page":"301","volume":"6","author":"Ramli N.","year":"2012","journal-title":"Aust. J. Basic Appl. Sci."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.11.007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-5923-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-011-0298-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf062330u"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.08.060"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb70425d"},{"key":"e_1_2_6_20_1","unstructured":"LIPIDS MAPS. Available:http:\/\/www.lipidmaps.org\/."},{"key":"e_1_2_6_21_1","unstructured":"Human Metabolome Database. Available:http:\/\/www.hmdb.ca\/."},{"key":"e_1_2_6_22_1","unstructured":"Massbank. Available:http:\/\/www.massbank.jp."},{"key":"e_1_2_6_23_1","unstructured":"Metlin database. Available:http:\/\/metlin.scripps.edu\/index.php."},{"key":"e_1_2_6_24_1","unstructured":"Chemspider. Available:http:\/\/www.chemspider.com\/."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.12.005"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr060594q"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/12081606"},{"key":"e_1_2_6_28_1","first-page":"326","volume":"44","author":"Saengkrajang W.","year":"2011","journal-title":"Thai J. Agric. Sci."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac203158u"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-013-9241-0"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0022-2275(20)32225-2","volume":"42","author":"Johnson D. W.","year":"2001","journal-title":"J. Lipid Res."},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7431"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.03.080"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)92338-Z"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/088532829601000304"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1210\/jcem.86.3.7327","volume":"86","author":"Lips P.","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.10.050"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2008.03.031"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf980094k"},{"key":"e_1_2_6_40_1","first-page":"143","volume":"20","author":"Kikuchi K.","year":"2002","journal-title":"J. Appl. Cosmetol."},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.291"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf901675y"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.12.098"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00267-008-9178-3"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2011.10.019"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-919X.2000.tb04459.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.09.094"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/jcrs.2002.0502"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2008.09.006"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300363b"},{"key":"e_1_2_6_51_1","first-page":"39","volume":"6","author":"Huda M. Z. N.","year":"2008","journal-title":"J. Food Technol."},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compag.2013.04.015"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(01)00584-0"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.05.067"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.6914","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.6914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.6914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:27:12Z","timestamp":1761496032000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.6914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,5]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,6,30]]}},"alternative-id":["10.1002\/rcm.6914"],"URL":"https:\/\/doi.org\/10.1002\/rcm.6914","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,5]]}}}