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Diagnosis is based on exclusion and is supported by thrombocytopenia in peripheral blood and characteristic megakaryocytic findings in bone marrow examination. In many adults, treatment remains suboptimal, and morbidity may result from both bleeding and the adverse effects of immunosuppressive therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Identifying the underlying disease process is essential for improving diagnostic precision, developing targeted therapies, and enhancing patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review summarizes mass spectrometry\u2010based proteomics studies investigating the pathogenesis of ITP and their diagnostic, prognostic, and therapeutic implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite significant clinical heterogeneity, proteomic research in ITP remains limited, underscoring the need for comprehensive molecular studies to better elucidate disease mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.70022","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:58:04Z","timestamp":1768910284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mass Spectrometry\u2010Based Proteomics to Understand Immune Thrombocytopenic Purpura: A Review"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-1311","authenticated-orcid":false,"given":"Syed\u00a0Kashif","family":"Raza","sequence":"first","affiliation":[{"name":"Department of Allied Health Sciences (AHS) University of Sargodha  Sargodha Punjab Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Institute of Medical Technology Jinnah Sindh Medical University (JSMU)  Karachi Sindh Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2703-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm921"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13861"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.106963"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24463"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2956"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2016.1219497"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01218.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009949"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-129155"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06024.x"},{"issue":"21","key":"e_1_2_9_16_1","first-page":"2829","article-title":"Clinical Updates in Adult Immune Thrombocytopenia","volume":"129","author":"Lambert M. 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