{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:22:37Z","timestamp":1783092157380,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2026,8,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Nitrite anion is among the highly reactive anions and converts the secondary amines to their corresponding carcinogenic N\u2010nitroso metabolites in the human body. Nitrite ion is highly abundant in natural waters and enters the body mainly through the consumption of water and beverages. The concentration of nitrite ion varies according to the nature of the soil, habitat and pollution in various geographical locations. Hence, it is important to assess the quality of water using novel analytical techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the present work, the concentration of nitrite ion from the collected water samples was monitored by N\u2010nitrosation reaction with 1,2,3,4\u2010tetrahydroquinoline (THQ) followed by quantification by liquid chromatography\u2013high\u2010resolution mass spectrometry using atmospheric chemical ionization on octadecyl stationary phase using water:methanol (both contain 0.2% formic acid) gradient elution. The N\u2010nitroso THQ levels were specifically monitored using high resolution selected ion monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The developed method was validated over the range of 1\u20135000\u2009ng\/mL, with recoveries of 81%\u2013119%. The limit of detection (LOD) and limit of quantification (LOQ) of the method were 1 and 2\u2009ng\/mL, respectively, yielding good linearity (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009&gt;\u20090.9996) and precision with a relative standard deviation less than 7% ranging from 3.2% to 6.2%. The water samples collected across 60 different areas showed nitrite ion concentrations ranging from 28.5 to 3177.0\u2009ng\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The derivatization procedure adopted in the present method is rapid and converts THQ to a stable NTHQ derivative in a single step. The results showed that water samples collected from residential areas, oceans, and mountains had the highest nitrite ion concentration. However, the clean, continuously flowing waters showed the lowest contamination, as the river beds act as effective filters for nitrite anions; hence, the water collected from these regions might be relatively clean compared to other regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.70101","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:41:11Z","timestamp":1778640071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liquid Chromatography\u2013High\u2010Resolution Mass Spectrometric Determination of Nitrite Ion Concentration in the Natural Water Resources"],"prefix":"10.1002","volume":"40","author":[{"given":"Sai Krishna","family":"Ganji","sequence":"first","affiliation":[{"name":"Centre for Mass Spectrometry, Analytical and Structural Chemistry Division CSIR\u2010Indian Institute of Chemical Technology  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3274-4616","authenticated-orcid":false,"given":"Kalpana","family":"Talari","sequence":"additional","affiliation":[{"name":"Centre for Mass Spectrometry, Analytical and Structural Chemistry Division CSIR\u2010Indian Institute of Chemical Technology  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1435-4440","authenticated-orcid":false,"given":"Rama Krishna","family":"Maloth","sequence":"additional","affiliation":[{"name":"Centre for Mass Spectrometry, Analytical and Structural Chemistry Division CSIR\u2010Indian Institute of Chemical Technology  Hyderabad Telangana India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya Sri Dharmika","family":"Kanakala","sequence":"additional","affiliation":[{"name":"Centre for Mass Spectrometry, Analytical and Structural Chemistry Division CSIR\u2010Indian Institute of Chemical Technology  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraju","family":"Rajana","sequence":"additional","affiliation":[{"name":"Centre for Mass Spectrometry, Analytical and Structural Chemistry Division CSIR\u2010Indian Institute of Chemical Technology  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyanarayana","family":"Gnv","sequence":"additional","affiliation":[{"name":"Centre for Mass Spectrometry, Analytical and Structural Chemistry Division CSIR\u2010Indian Institute of Chemical Technology  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraju","family":"Maddala","sequence":"additional","affiliation":[{"name":"Centre for Mass Spectrometry, Analytical and Structural Chemistry Division CSIR\u2010Indian Institute of Chemical Technology  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chemalamarri","family":"Chandrashekhar","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunitha","family":"Reddy M","sequence":"additional","affiliation":[{"name":"Centre for Pharmaceutical Sciences JNTUH University College of Engineering, Science &amp; Technology  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4390-454X","authenticated-orcid":false,"given":"Vijayasarathi V. 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