{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:14:17Z","timestamp":1788264857140,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>\n                      In this study, the phytochemical composition, in\u00a0vitro anticancer activity, photodynamic therapy (PDT) activity, and molecular interaction potential with carbonic anhydrase IX (CA IX) of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Cakile maritima<\/jats:italic>\n                      <\/jats:styled-content>\n                      methanol extract were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      LC\u2013MS\/MS analysis identified 11 compounds among 35 screened phytochemicals, with fumaric acid (13797.19\u2009ppb), ferulic acid (771.37\u2009ppb) and p\u2010coumaric acid (601.95\u2009ppb) accounting for approximately 97% of the total content. Molecular docking results demonstrated that sinapic acid (\u22126.13\u2009kcal\/mol) and quinic acid (\u22126.11\u2009kcal\/mol) exhibited the highest binding affinities toward CA IX. Cell culture studies revealed that LogIC\n                      <jats:sub>50<\/jats:sub>\n                      values differed significantly among cell lines (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). PDT applied to the MKN\u201028 gastric cancer cell line significantly enhanced cytotoxicity compared with the control group, with the highest photodynamic efficacy observed under green\u2010light irradiation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings indicate that\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. maritima<\/jats:italic>\n                      <\/jats:styled-content>\n                      methanol extract exhibits light\u2010enhanced cytotoxicity in MKN\u201028 gastric cancer cells and warrant further investigation regarding its potential photosensitising properties.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.70143","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:23:26Z","timestamp":1784661806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LC\u2013MS\/MS\u2010Based Phytochemical Characterization of\n                    <scp>\n                      <i>Cakile maritima<\/i>\n                    <\/scp>\n                    Methanol Extract and Its Photodynamic Anticancer Activity in Gastric Cancer Cells"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8464-5487","authenticated-orcid":false,"given":"Sercin Ozlem","family":"Caliskan","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Biophysics Usak University  Usak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biology Usak University  Usak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-0067","authenticated-orcid":false,"given":"Emine \u0130ncilay","family":"Toruno\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biochemistry Necmettin Erbakan University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-3283","authenticated-orcid":false,"given":"Alper","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Ali Nihat G\u00f6kyi\u011fit Botanical Garden Application and Research Center Artvin Coruh University  Artvin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abidin","family":"G\u00fcmr\u00fck\u00e7\u00fco\u011flu","sequence":"additional","affiliation":[{"name":"Medicinal\u2010Aromatic Plants Application and Research Center Artvin \u00c7oruh University  Artvin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-0183","authenticated-orcid":false,"given":"Erdi Can","family":"Aytar","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Department of Horticulture Usak University  Usak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010020\u20100926\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2012.10.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010018\u20100140\u2010z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101269715"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20513"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150942"},{"key":"e_1_2_11_8_1","first-page":"1","volume-title":"The Journey of PDT Throughout History: PDT From Pharos to Present","author":"Abdel\u2010Kader M. 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