{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:52:05Z","timestamp":1791301925960,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["FWP 84052"],"award-info":[{"award-number":["FWP 84052"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2026,11,30]]},"abstract":"ABSTRACT<\/jats:title>\n \n Rationale<\/jats:title>\n \n Clumped isotope geochemistry can reveal the temperatures and chemical pathways at which molecules form, but it remains unexplored for most inorganic systems. Iodate (IO\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n ) is central to ocean and atmospheric iodine cycling and to tracking radioactive iodine from nuclear activity. Here, we report the first exploratory investigation into the feasibility of measuring bulk and clumped isotopologues in iodate using electrospray ionization mass spectrometry (ESI\u2010MS).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Sodium iodate was dissolved in either deionized water or 97% H\n 2<\/jats:sub>\n 18<\/jats:sup>\n O. Two sample sets systematically varied the H\n 2<\/jats:sub>\n 18<\/jats:sup>\n O fraction of the spray solvent from 0% to 97%. Samples were infused into a Thermo Scientific TSQ Quantum Access MAX triple\u2010quadrupole mass spectrometer with an atmospheric pressure ionization source operated in negative\u2010ion scan mode. Spectra were acquired over\n m\/z<\/jats:italic>\n 110\u2013190 and averaged across 25 scans.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The singly substituted isotopologue (\n 127<\/jats:sup>\n I\n 16<\/jats:sup>\n O\n 2<\/jats:sub>\n 18<\/jats:sup>\n O\n \u2212<\/jats:sup>\n ,\n m\/z<\/jats:italic>\n 177), clumped isotopologues (\n 127<\/jats:sup>\n I\n 16<\/jats:sup>\n O\n 18<\/jats:sup>\n O\n 2<\/jats:sub>\n \u2212<\/jats:sup>\n ,\n m\/z<\/jats:italic>\n 179;\n 127<\/jats:sup>\n I\n 18<\/jats:sup>\n O\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n ,\n m\/z<\/jats:italic>\n 181), and isotopologue distributions were resolved in IO\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n . Relative isotopologue abundances shifted monotonically with solvent\n 18<\/jats:sup>\n O content;\n 127<\/jats:sup>\n I\n 18<\/jats:sup>\n O\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n increased from 0% to 56% across the enrichment range. In the natural abundance sample, measured isotopologue abundances matched the values predicted for a stochastic (random) isotope distribution, confirming that the instrument is sampling the natural isotopologue distribution without significant bias. We also report isotopologue distributions for IO\n \u2212<\/jats:sup>\n and IO\n 2<\/jats:sub>\n \u2212<\/jats:sup>\n , which exhibit isotopic trends similar to those observed for IO\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These first measurements of isotopologues in IO\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n establish ESI\u2010MS as an accessible platform for isotopic analysis of inorganic oxyanions under enriched conditions. We discuss the thermodynamic basis for equilibrium clumping in IO\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n , the analytical requirements for extending these enriched sample measurements to natural abundance clumped isotope thermometry, and the potential applications of this system in Earth and nuclear sciences.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/rcm.70161","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:21:20Z","timestamp":1788859280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory Measurements of Singly Substituted and Clumped Isotopologues in Iodate Using Electrospray Ionization Mass Spectrometry"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9104-2518","authenticated-orcid":false,"given":"Jamie","family":"Lucarelli","sequence":"first","affiliation":[{"name":"Department of Earth, Planetary, and Space Sciences UCLA Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R.","family":"Bubas","sequence":"additional","affiliation":[{"name":"Pacific Northwest National Laboratory Richland Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1812-3431","authenticated-orcid":false,"given":"Richard M","family":"Cox","sequence":"additional","affiliation":[{"name":"Pacific Northwest National Laboratory Richland Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8853-0257","authenticated-orcid":false,"given":"Sophie B.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Pacific Northwest National Laboratory Richland Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aradhna","family":"Tripati","sequence":"additional","affiliation":[{"name":"Department of Earth, Planetary, and Space Sciences UCLA Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Engelmann","sequence":"additional","affiliation":[{"name":"Pacific Northwest National Laboratory Richland Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise R.","family":"Conte","sequence":"additional","affiliation":[{"name":"Pacific Northwest National Laboratory Richland Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2005.11.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsl.2007.08.020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2004.05.039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2004.05.035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b04486"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c06533"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2021.07.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1029\/2022GC010458"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq0611"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2013.10.045"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4326"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2305574120"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1029\/2012JD017992"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aao6741"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c02966"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.7671"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.8836"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.8323"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemgeo.2022.121278"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2017.12.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2025.02.017"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4EM00139G"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspa.2020.0824"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsl.2020.116676"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01465a006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marchem.2021.104000"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ngeo1687"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.5194\/acp-14-13119-2014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0048-9697(99)00122-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.11.013"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10643389.2013.828273"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nimb.2004.04.107"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/282574"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020\u20107381(83)85053\u20100"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/DT9760001683"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/jr9470000562"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1746492"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0584\u20108547(99)00110\u2010X"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9813742"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20247"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac50036a020"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1029\/2017GC007385"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.70161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcm.70161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.70161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:54:18Z","timestamp":1791298458000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.70161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":42,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,11,30]]}},"alternative-id":["10.1002\/rcm.70161"],"URL":"https:\/\/doi.org\/10.1002\/rcm.70161","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"2026-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70161"}}