{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:51:38Z","timestamp":1791301898561,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2026,11,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>\n                      High\u2010resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications demand instrumentation to be capable of combining sub\u2010ppm mass accuracy, high resolving power, rapid full\n                      <jats:italic>m\/z<\/jats:italic>\n                      range acquisition over a wide dynamic range.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Achieving the above requirements places constraints on analyzer design and performance. Multi\u2010reflecting time\u2010of\u2010flight (MRT) based analyzers have previously been reported as a means of significantly extending the effective flight path in compact TOF designs. Here, further instrument and functionality advances in a compact MRT mass spectrometer design are described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The impact of these enhancements was assessed for targeted and non\u2010targeted omics applications, examining the impact of acquisition speed on resolving power, dynamic range including limits of quantitation, and quantitative precision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results obtained characterize the performance of the enhanced design features of a compact MRT mass spectrometer. Operation at elevated acquisition rates up to 200\u2009Hz was observed without loss in resolving power, isotopic ratio accuracy or quantitative precision.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.70173","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:11:51Z","timestamp":1788959511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in the Design and Functionality of a Compact Multi\u2010Reflecting Time\u2010of\u2010Flight Mass Spectrometer"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4098-6975","authenticated-orcid":false,"given":"Jason","family":"Wildgoose","sequence":"first","affiliation":[{"name":"Waters Corporation  Wilmslow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0176-2907","authenticated-orcid":false,"given":"Samantha","family":"Ferries","sequence":"additional","affiliation":[{"name":"Waters Corporation  Wilmslow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3513-364X","authenticated-orcid":false,"given":"Lee A.","family":"Gethings","sequence":"additional","affiliation":[{"name":"Waters Corporation  Wilmslow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-8477","authenticated-orcid":false,"given":"Matthew E.","family":"Daly","sequence":"additional","affiliation":[{"name":"Waters Corporation  Wilmslow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1658-9334","authenticated-orcid":false,"given":"Martin E.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Waters Corporation  Wilmslow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0078-139X","authenticated-orcid":false,"given":"Richard","family":"Lock","sequence":"additional","affiliation":[{"name":"Waters Corporation  Wilmslow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6283-8456","authenticated-orcid":false,"given":"Johannes P. 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