{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:14:01Z","timestamp":1790381641012,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2015,12,15]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The ability of membrane introduction mass spectrometry to quantitatively resolve low molecular weight volatile organic compounds (VOCs) such as benzene, toluene, ethylbenzene and xylene (BTEX) using electron ionization (EI) can be compromised by isobaric interferences. This work focuses on reducing isobaric interferences with ion\u2010molecule reactions in a portable quadrupole ion trap mass spectrometer for the analysis of VOCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EI was used to produce reagent ions from precursors (chloroform, methyl iodide, trichloroethylene or chlorobenzene) that were continually infused into the helium acceptor phase upstream of the membrane introduction mass spectrometry (MIMS) sampling interface. The reagent ions were selectively stored in the ion trap, and then allowed to react with target VOC analytes in air samples via ion\u2010molecule reactions within the trap storage volume. A variety of reaction times were examined (50\u20135000\u00a0ms), and the resulting product ions were analyzed in positive ion mode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The detection limits achieved were comparable with those obtained using EI (low ppb\n                      <jats:sub>v<\/jats:sub>\n                      ), and in some cases better than for EI coupled with tandem mass spectrometry (MS\/MS). For the VOCs studied, isobaric interferences were greatly reduced or eliminated using chloroform as a reagent gas. The predominant ionization mechanism was via adduct formation, although charge transfer and hydride abstractions were also observed. An internal standard was shown to be effective at correcting for signal changes due to consumption of reagent ions when complex mixtures were sampled.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ion\u2010molecule reactions were exploited to eliminate isobaric interferences that are often encountered in direct, real\u2010time analysis strategies for atmospheric VOC mixtures. The use of a continuously infused internal standard will improve quantitative results in field applications where analyte concentration and sample complexity may be wide ranging. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.7380","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T04:22:12Z","timestamp":1446006132000},"page":"2187-2194","source":"Crossref","is-referenced-by-count":9,"title":["A membrane introduction mass spectrometer utilizing ion\u2010molecule reactions for the on\u2010line speciation and quantitation of volatile organic molecules"],"prefix":"10.1002","volume":"29","author":[{"given":"Nicholas G.","family":"Davey","sequence":"first","affiliation":[{"name":"Chemistry Department University of Victoria  Victoria BC Canada"},{"name":"Applied Environmental Research Laboratories (AERL), Chemistry Department Vancouver Island University  Nanaimo BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Bell","sequence":"additional","affiliation":[{"name":"Applied Environmental Research Laboratories (AERL), Chemistry Department Vancouver Island University  Nanaimo BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik T.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Chemistry Department University of Victoria  Victoria BC Canada"},{"name":"Applied Environmental Research Laboratories (AERL), Chemistry Department Vancouver Island University  Nanaimo BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris G.","family":"Gill","sequence":"additional","affiliation":[{"name":"Chemistry Department University of Victoria  Victoria BC Canada"},{"name":"Applied Environmental Research Laboratories (AERL), Chemistry Department Vancouver Island University  Nanaimo BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-anchem-060908-155229"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1255\/ejms.1036"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2011.05.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4236\/jep.2013.48A1012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-9936(04)00404-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/es070905d"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2008.07.021"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4360"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00212a013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac970263k"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3250"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/es9019468"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2134\/jeq2009.0184"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10934529.2014.910014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-014-1028-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3000"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2787(2000)19:1<1::AID-MAS1>3.0.CO;2-Y"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.327"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3447"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-36756-X"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2009.09.018"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00283a043"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2670(92)85274-A"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00035a003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac960039f"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac980407a"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/es025776"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/es034423n"},{"key":"e_1_2_6_30_1","first-page":"312","article-title":"Improving the selectivity of non\u2010polar alkanes, alkenes, and aromatic hydrocarbon compounds by the application of acetonitrile as a Cl reagent","volume":"7","author":"Alwedian F.","year":"2009","journal-title":"Cent. 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