{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:04:26Z","timestamp":1791918266301,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2017,5,15]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>This paper highlights the versatility of interfacing two ambient ionization techniques, Laser Diode Thermal Desorption (LDTD) and Atmospheric Solids Analysis Probe (ASAP), to high\u2010resolution mass spectrometers and demonstrate the method's capability to rapidly generate high\u2010quality data from multiple sample types with minimal, if any, sample preparation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For ASAP\u2010MS analysis of solid and liquid samples, the material was transferred to a capillary surface before being introduced into the mass spectrometer. For LDTD\u2010MS analysis, samples were solvent extracted, spotted in a 96\u2010well plate, and the solvent was evaporated before being introduced into the mass spectrometer. All analyses were performed using Atmospheric Pressure Chemical Ionization in positive mode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven consumer \"Spice\" packets were combined and analyzed by both ASAP and LDTD, which identified 11 synthetic cannabinoids\/cathinones by full MS and MS\/MS experiments. To further show the usefulness of these techniques, black tar heroin was analyzed, which resulted in the identification of heroin and its impurities (monoacetylmorphine, papaverine, and noscapine). These experiments were performed on the LTQ\u2010Orbitrap to demonstrate the ability to perform both parallel and serial MS and MS\n                      <jats:sup>n<\/jats:sup>\n                      experiments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Interfacing LDTD and ASAP to high\u2010resolution mass spectrometers allows for expeditious analysis of a wide range of samples, with minimal or no sample preparation. Both allow for rapid full scan, MS\/MS, and\/or MS\n                      <jats:sup>n<\/jats:sup>\n                      experiments from a single sample introduction. Published in 2017. This article is a U.S. Government work and is in the public domain in the USA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.7844","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T08:22:57Z","timestamp":1488788577000},"page":"782-790","source":"Crossref","is-referenced-by-count":21,"title":["Rapid analysis of forensic\u2010related samples using two ambient ionization techniques coupled to high\u2010resolution mass spectrometers"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-7785","authenticated-orcid":false,"given":"Eshwar","family":"Jagerdeo","sequence":"first","affiliation":[{"name":"Federal Bureau of Investigation Laboratory  Quantico VA 22135 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Wriston","sequence":"additional","affiliation":[{"name":"Federal Bureau of Investigation Laboratory  Quantico VA 22135 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2675315"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104404"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.922"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408129111"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/B418697D"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b03010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5AY00511F"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2012.06.015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3718"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2006.08.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac8001935"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2014.05.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5016408"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac402798m"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac051470k"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1424"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.7097"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-016-1349-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2714"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac900063u"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b02684"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac900682f"},{"key":"e_1_2_6_25_1","first-page":"8","article-title":"Direct analysis in real time (DARTtm) mass spectrometry","volume":"40","author":"Cody R. 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