{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:38:58Z","timestamp":1792237138678,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2017,11,30]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The linear intrascan and interscan dynamic ranges of mass spectrometers are important in metabolome and residue analysis. A large linear dynamic range is mandatory if both low\u2010 and high\u2010abundance ions have to be detected and quantitated in heavy matrix samples. These performance criteria, as provided by modern high\u2010resolution mass spectrometry (HRMS), were systematically investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The comparison included two generations of Orbitraps, and an ion mobility quadrupole time\u2010of\u2010flight (QTOF) system In addition, different scan modes, as provided by the utilized instruments, were investigated. Calibration curves of different compounds covering a concentration range of five orders of magnitude were measured to evaluate the linear interscan dynamic range. The linear intrascan dynamic range and the resulting mass accuracy were evaluated by repeating these measurements in the presence of a very intense background.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Modern HRMS instruments can show linear dynamic ranges of five orders of magnitude. Often, however, the linear dynamic range is limited by the detection capability (sensitivity and selectivity) and by the electrospray ionization. Orbitraps, as opposed to TOF instruments, show a reduced intrascan dynamic range. This is due to the limited C\u2010trap and Orbitrap capacity. The tested TOF instrument shows poorer mass accuracies than the Orbitraps. In contrast, hyphenation with an ion\u2010mobility device seems not to affect the linear dynamic range.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The linear dynamic range of modern HRMS instrumentation has been significantly improved. This also refers to the virtual absence of systematic mass shifts at high ion abundances. The intrascan dynamic range of the current Orbitrap technology may still be a limitation when analyzing complex matrix extracts. On the other hand, the linear dynamic range is not only limited by the detector technology, but can also be shortened by peripheral devices, where the ionization and transfer of ions take place.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.7981","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T21:56:45Z","timestamp":1504648605000},"page":"1915-1926","source":"Crossref","is-referenced-by-count":45,"title":["Comparison of linear intrascan and interscan dynamic ranges of Orbitrap and ion\u2010mobility time\u2010of\u2010flight mass spectrometers"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-8892","authenticated-orcid":false,"given":"Anton","family":"Kaufmann","sequence":"first","affiliation":[{"name":"Official Food Control Authority  Fehrenstrasse 15 8032 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Walker","sequence":"additional","affiliation":[{"name":"Official Food Control Authority  Fehrenstrasse 15 8032 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.08.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000166"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201501137"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b02515"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2014.07.039"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2011.09.063"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6195"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac203137n"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac502984a"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2004.04.034"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2013.12.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2014.06.025"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2014.04.005"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2762"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-014-0961-5"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2006.03.006"},{"key":"e_1_2_5_18_1","article-title":"Targeted data extraction of the MS\/MS spectra generated by data\u2010independent acquisition: A new concept for consistent and accurate proteome analysis","author":"Gillet LC","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.10.017"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.05.017"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.7530"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.01.039"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.05.002"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-016-1346-8"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300775k"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20186"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-5629-4"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4615"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.7981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.7981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T10:56:05Z","timestamp":1761476165000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.7981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,16]]},"references-count":27,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2017,11,30]]}},"alternative-id":["10.1002\/rcm.7981"],"URL":"https:\/\/doi.org\/10.1002\/rcm.7981","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,16]]}}}