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With several antipsychotic drugs currently available all over the world, this class of drugs has quickly gained importance in both the clinical and forensic context. This work describes the development and validation of a methodology for the determination of seven antipsychotic drugs in plasma and oral fluid samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The antipsychotic drugs (chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, cyamemazine and, levomepromazine) were isolated from 0.2\u00a0mL of oral fluid and 0.5\u00a0mL of plasma using solid\u2010phase extraction (SPE) following analysis by gas chromatography\/tandem mass spectrometry (GC\/MS\/MS). The method was validated according to the international guidelines in terms of selectivity, linearity, accuracy, precision and recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The procedure was linear within 2\u2013600\u00a0ng\/mL (plasma) and 2\u2013400\u00a0ng\/mL (oral fluid), the intervals varying according to the compound; a mean R\n                      <jats:sup>2<\/jats:sup>\n                      value of 0.99 was obtained and the calibrator's accuracy (mean relative error) was within a \u00b115 % interval for all concentrations. The limits of detection ranged from 1 to 10\u00a0ng\/mL. Within\u2010 and between\u2010run precision and accuracy were acceptable for all studied compounds. The extraction efficiency of the process ranged from 79% to 95%. The method was applied to authentic specimens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The described method was proven selective and sensitive for the determination of antipsychotics in low sample volumes using SPE and GC\/MS\/MS. This method was considered suitable not only for routine analysis of patients undergoing antipsychotic treatment (to evaluate compliance), but also in forensic scenarios where the studied compounds may be involved. To the best of our knowledge, this is the first work that reports the determination of antipsychotic drugs in oral fluid using MS\/MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8087","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T19:42:45Z","timestamp":1518723765000},"page":"2081-2095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Development and validation of a gas chromatography\/tandem mass spectrometry method for simultaneous quantitation of several antipsychotics in human plasma and oral fluid"],"prefix":"10.1002","volume":"32","author":[{"given":"Tiago","family":"Rosado","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade da Beira Interior (CICS\u2010UBI)  Covilh\u00e3 Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco\u2010Toxicologia\u2013UBIMedical Universidade da Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Oppolzer","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade da Beira Interior (CICS\u2010UBI)  Covilh\u00e3 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Cruz","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade da Beira Interior (CICS\u2010UBI)  Covilh\u00e3 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio","family":"Barroso","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Qu\u00edmica e Toxicologia Forenses Instituto Nacional de Medicina Legal e Ci\u00eancias Forenses  Delega\u00e7\u00e3o do Sul Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Varela","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Cova da Beira, E.P.E Departamento de Psiquiatria e Sa\u00fade Mental  Covilh\u00e3 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Cova da Beira, E.P.E Departamento de Psiquiatria e Sa\u00fade Mental  Covilh\u00e3 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Cova da Beira, E.P.E Departamento de Psiquiatria e Sa\u00fade Mental  Covilh\u00e3 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-8998","authenticated-orcid":false,"given":"Eugenia","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade da Beira Interior (CICS\u2010UBI)  Covilh\u00e3 Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco\u2010Toxicologia\u2013UBIMedical Universidade da Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization. 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