{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:04:42Z","timestamp":1769267082623,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2014CFB784"],"award-info":[{"award-number":["2014CFB784"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21675176"],"award-info":[{"award-number":["21675176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2018,12,15]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Gallic acid is one of the most common polyphenols in natural products and human diet. The consumption of gallic acid reduces the incidence of cardiovascular diseases, chronic metabolic disorders and cancers. Most previous publications focused on the antioxidative or prooxidative properties of gallic acid. In the present work, gallic acid as a trapping agent of blood formaldehyde was investigated by liquid chromatography\/tandem mass spectrometry (LC\/MS\/MS) and neutral loss scan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples incubated with gallic acid were subjected to LC\/MS\/MS analysis using an LTQ XL ion trap mass spectrometer. The adduct ions of gallic acid\u2010formaldehyde\u2010amino acids were explored by investigation of their fragmentation patterns and neutral loss scan experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A series of Mannich adducts (namely, gallic acid\u2010formaldehyde\u2010alanine, gallic acid\u2010formaldehyde\u2010proline, gallic acid\u2010formaldehyde\u2010leucine or gallic acid\u2010formaldehyde\u2010isoleucine and gallic acid\u2010formaldehyde\u2010phenylalanine) were identified as metabolites by neutral loss scan experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This work demonstrated that serum amino acids are involved in gallic acid detoxification of formaldehyde. Because excessive formaldehyde in blood is implicated in a variety of disease pathologies, detoxification of formaldehyde, especially endogenous formaldehyde, may be another health beneficial effect of gallic acid. It also suggested that more attention should be paid to Mannich\u2010type metabolites of polyphenol\u2010formaldehyde\u2010amino acids in research into the pharmacokinetics and bioavailability of polyphenols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8278","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T11:25:02Z","timestamp":1536319502000},"page":"2074-2080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Investigation of serum amino acids involved in gallic acid detoxification of formaldehyde by liquid chromatography\/tandem mass spectrometry and neutral loss scan"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8600-6566","authenticated-orcid":false,"given":"Hai\u2010peng","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Pharmacy Wuhan Institute of Technology  Wuhan 430205 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Pharmacy Wuhan Institute of Technology  Wuhan 430205 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010lian","family":"Ju","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Pharmacy Wuhan Institute of Technology  Wuhan 430205 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of State Ethnic Affairs Commission, College of Chemistry and Materials Science South\u2010Central University for Nationalities  Wuhan 430074 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry of State Ethnic Affairs Commission, College of Chemistry and Materials Science South\u2010Central University for Nationalities  Wuhan 430074 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"issue":"9","key":"e_1_2_6_2_1","first-page":"4382","article-title":"Carcinogenicity of formaldehyde in rats and mice after long\u2010term inhalation exposure","volume":"43","author":"Kerns WD","year":"1983","journal-title":"Cancer Res"},{"issue":"9","key":"e_1_2_6_3_1","first-page":"3398","article-title":"Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapor","volume":"40","author":"Swenberg JA","year":"1980","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.867023"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002170050169"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2011.02845.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.08.020"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-010-4112-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23481"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600996200"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00142-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9388-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.05.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.04.013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/i8090950"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.10.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu2111106"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408391003698677"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961764"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-005-7497-8"},{"issue":"25","key":"e_1_2_6_21_1","first-page":"125","article-title":"Wine and polyphenols related to platelet aggregation and atherothrombosis","volume":"25","author":"Ruf JC","year":"1999","journal-title":"Drugs Exp Clin Res"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2003275"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf030117h"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.4.1207"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00035a014"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960040"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-012-1907-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx700190s"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955708783955953"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac981022v"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2453"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-002-0338-0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.4306"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.8278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.8278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:59:33Z","timestamp":1761494373000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.8278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":32,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2018,12,15]]}},"alternative-id":["10.1002\/rcm.8278"],"URL":"https:\/\/doi.org\/10.1002\/rcm.8278","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,5]]},"assertion":[{"value":"2018-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}