{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:46:30Z","timestamp":1790441190395,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["NPRP 6 \u2010 334 \u2010 3 \u2010 087"],"award-info":[{"award-number":["NPRP 6 \u2010 334 \u2010 3 \u2010 087"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["NPRP 6\u2010334\u20103\u2010087"],"award-info":[{"award-number":["NPRP 6\u2010334\u20103\u2010087"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2018,12,15]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The World Anti\u2010Doping Agency (WADA) encourages drug\u2010testing laboratories to develop screening methods that can detect as many doping substances as possible in urine. The use of full\u2010scan high\u2010resolution acquisition (FS\/HR) with gas chromatography\/mass spectrometry (GC\/MS) for the detection of known and unknown trimethylsilyl (TMS) derivatives of anabolic\u2010androgenic steroids (AAS) provides anti\u2010doping testing bodies with a new analytical tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The AAS were extracted from urine samples by generic liquid\u2013liquid extraction, after enzymatic hydrolysis, and TMS derivatization. The extracted urine was analyzed by GC\/Q\u2010TOF and GC\/Q\u2010Orbitrap to compare the performance of the two instrument types for the detection of 46 AAS in human urine. The quantitation of endogenous anabolic steroids and the ability of the two analytical platforms to comply with the requirements for testing as part of the WADA Athlete Biological Passport (ABP) were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The data presented show that the analytical performance for both instruments complies with the WADA specifications. The limits of detection (LODs) for both instruments are well below the WADA 50% Minimum Required Performance Levels. The mass errors in the current study for the GC\/Q\u2010Orbitrap platform are lower than those obtained for the GC\/Q\u2010TOF instrument.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The data presented herein proved that both molecular profiling platforms can be used for antidoping screening. The mass accuracies are excellent in both instruments; however, the GC\/Q\u2010Orbitrap performs better as it provides higher resolution than the GC\/Q\u2010TOF platform.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8281","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T15:30:53Z","timestamp":1536939053000},"page":"2055-2064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of gas chromatography\/quadrupole time\u2010of\u2010flight and quadrupole Orbitrap mass spectrometry in anti\u2010doping analysis: I. Detection of anabolic\u2010androgenic steroids"],"prefix":"10.1002","volume":"32","author":[{"given":"Wadha","family":"Abushareeda","sequence":"first","affiliation":[{"name":"Anti\u2010Doping Lab Qatar  Sports City Road, P.O. Box 27775, Sports City Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Tienstra","sequence":"additional","affiliation":[{"name":"RIKILT Wageningen University  P.O. Box 230 6700 AE Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen","family":"Lommen","sequence":"additional","affiliation":[{"name":"RIKILT Wageningen University  P.O. Box 230 6700 AE Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Blokland","sequence":"additional","affiliation":[{"name":"RIKILT Wageningen University  P.O. Box 230 6700 AE Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Sterk","sequence":"additional","affiliation":[{"name":"RIKILT Wageningen University  P.O. Box 230 6700 AE Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhail","family":"Kraiem","sequence":"additional","affiliation":[{"name":"Anti\u2010Doping Lab Qatar  Sports City Road, P.O. Box 27775, Sports City Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Horvatovich","sequence":"additional","affiliation":[{"name":"University of Groningen  P.O. Box 196 9700 AD Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Nielen","sequence":"additional","affiliation":[{"name":"RIKILT Wageningen University  P.O. Box 230 6700 AE Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Al\u2010Maadheed","sequence":"additional","affiliation":[{"name":"Anti\u2010Doping Lab Qatar  Sports City Road, P.O. Box 27775, Sports City Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-1243","authenticated-orcid":false,"given":"Costas","family":"Georgakopoulos","sequence":"additional","affiliation":[{"name":"Anti\u2010Doping Lab Qatar  Sports City Road, P.O. Box 27775, Sports City Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Anti\u2010doping Agency (WADA) Prohibited List(2018).https:\/\/www.wada\u2010ama.org\/sites\/default\/files\/prohibited_list_2018_en.pdf. Accessed April 25 2018."},{"key":"e_1_2_6_3_1","unstructured":"World Anti\u2010Doping Agency (WADA) International Standard for Laboratories(ISL2016).https:\/\/www.wada\u2010ama.org\/sites\/default\/files\/resources\/files\/isl_june_2016.pdf. Accessed October 14 2017."},{"key":"e_1_2_6_4_1","unstructured":"World Anti\u2010doping Agency (WADA)TD2018MRPL.https:\/\/www.wada\u2010ama.org\/sites\/default\/files\/resources\/files\/td2018mrpl_v1_finaleng.pdf. Accessed April 25 2018."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20107"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2714"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3103"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.10.042"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2227"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.08.019"},{"key":"e_1_2_6_11_1","unstructured":"World Anti\u2010Doping Agency.Endogenous Anabolic Androgenic Steroids: Measurement and Reporting. TD2016EAAS version 1.0.https:\/\/www.wada\u2010ama.org\/en\/resources\/science\u2010medicine\/td2016\u2010eaas. Accessed October 14 2017."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2010.11.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.08.033"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21443"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.04.024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3182-8_20"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2015.02.054"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b01404"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.06.017"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2017.05.023"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.12.146"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.14.9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2013.08.010"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2011.11.004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-013-7218-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2014-093510"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)91836-3"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.8281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.8281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:59:24Z","timestamp":1761494364000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.8281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":26,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2018,12,15]]}},"alternative-id":["10.1002\/rcm.8281"],"URL":"https:\/\/doi.org\/10.1002\/rcm.8281","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,5]]},"assertion":[{"value":"2018-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}