{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:29:07Z","timestamp":1769171347744,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>High mass and high spatial resolution matrix\u2010assisted laser desorption\/ionization (MALDI) imaging mass spectrometry (IMS) opens new possibilities for the detailed study of the hepatic metabolism of drugs. The spatial and temporal distribution of drug metabolites within liver lobules, anatomical subunits of the liver, may aid in the understanding of the formation of reactive metabolites that bind to liver proteins and cause drug\u2010induced liver injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Frozen livers obtained from rats dosed orally with amodiaquine (100\u2009mg\/kg) were sectioned at 10\u2009\u03bcm and coated with a MALDI matrix. The liver sections were then analyzed using a Fourier transform ion cyclotron resonance mass spectrometer. Images corresponding to amodiaquine and its metabolites were obtained at a spatial resolution of 25\u2009\u03bcm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Molecular images of amodiaquine within liver lobules have higher intensities near the portal triad and lower intensities near the central vein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that MALDI IMS can be used to investigate the metabolism of drugs within liver lobules. The results are consistent with existing knowledge of amodiaquine metabolism and reactive metabolite formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8339","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T06:52:13Z","timestamp":1541400733000},"page":"252-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Investigation of amodiaquine localization in liver lobules using matrix\u2010assisted laser desorption\/ionization imaging mass spectrometry"],"prefix":"10.1002","volume":"33","author":[{"given":"Kerri J.","family":"Grove","sequence":"first","affiliation":[{"name":"Novartis Institutes for Biomedical Research  Emeryville CA 94608 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaila","family":"Hoque","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research  Emeryville CA 94608 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