{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:39:10Z","timestamp":1778769550034,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2020,5,30]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Determination of phosphine exposure from zinc or aluminum phosphide fumigants continues to be a routine analytical requirement in veterinary forensic toxicology. There is a need for a more reliable and specific method than simple gas chromatography\/mass spectrometry (GC\/MS) analysis of sample solvent extracts, as GC\/MS of extracts on capillary columns used for general screens involves significant interference from air peaks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>GC\/MS\/MS headspace analysis of acid\u2010generated phosphine gas enabled study of the feasibility of devising multiple reaction monitoring (MRM) approaches to the determination of phosphine with greater specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Collision\u2010induced dissociation in GC\/MS\/MS showed that phosphine generated\n                      <jats:italic>m<\/jats:italic>\n                      \/\n                      <jats:italic>z<\/jats:italic>\n                      34 \u2192 31, 32 and 33 ion transitions by sequential proton release as well as minor transitions\n                      <jats:italic>m<\/jats:italic>\n                      \/\n                      <jats:italic>z<\/jats:italic>\n                      34 \u2192 47, 34 \u2192 63 and 63 \u2192 31.5 by intermolecular collisions and double charging. Study of the formation of these product ions enabled development of MRM settings for a highly useful headspace method for phosphine detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The method was validated over a working range of 5\u2013100\u2009ppm of phosphide generating phosphine gas which enabled retention of regular screen capillary columns without necessitating separation from air components. The method should have adequate sensitivity and reliability for veterinary toxicology laboratories confronting specimens from animals poisoned by crop fumigants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8738","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T21:55:03Z","timestamp":1579902903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phosphine detection in veterinary samples using headspace gas chromatography\/tandem mass spectrometry with multiple reaction monitoring"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-5684","authenticated-orcid":false,"given":"Andreas F.","family":"Lehner","sequence":"first","affiliation":[{"name":"Michigan State University Veterinary Diagnostic Laboratory Toxicology Section, Michigan State University  Lansing MI 48910 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Johnson","sequence":"additional","affiliation":[{"name":"Michigan State University Veterinary Diagnostic Laboratory Toxicology Section, Michigan State University  Lansing MI 48910 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4077-5014","authenticated-orcid":false,"given":"John P.","family":"Buchweitz","sequence":"additional","affiliation":[{"name":"Michigan State University Veterinary Diagnostic Laboratory Toxicology Section, Michigan State University  Lansing MI 48910 USA"},{"name":"Michigan State University College of Veterinary Medicine, Department of Pathobiology &amp; Diagnostic Investigation Michigan State University  East Lansing MI 48910 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/494168"},{"key":"e_1_2_5_3_1","unstructured":"SandersonRT.Nitrogen group element: chemical element group.Encyclopedia Britannica.2019;https:\/\/www.britannica.com\/science\/nitrogen-group-element. 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Accepted 5 January2015 Modified 23 August 2016.http:\/\/www.aorc-online.org\/documents\/aorc-ms-criteria-modified-23-aug-16\/Sept2019."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic50005a014"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic50005a015"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.8738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.8738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcm.8738","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.8738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T11:08:20Z","timestamp":1761476900000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.8738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,9]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,5,30]]}},"alternative-id":["10.1002\/rcm.8738"],"URL":"https:\/\/doi.org\/10.1002\/rcm.8738","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,9]]},"assertion":[{"value":"2019-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8738"}}