{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:16:11Z","timestamp":1778955371738,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017JL012"],"award-info":[{"award-number":["ZR2017JL012"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21677085"],"award-info":[{"award-number":["21677085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2020,5,30]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Sedatives, which are prone to cause residues in animals, have been abused in modern animal husbandry. Long\u2010term consumption of contaminated meat products would be unfavorable to the human nervous system. Taking into account public health and food safety, it was essential to develop an effective method for the enrichment and detection of sedatives in meat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @TbBd@ZIF\u20108 composites were synthesized by using Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      nanoparticles as a magnetic core and 1,3,5\u2010triformylbenzene (Tb) and benzidine (Bd) as two building blocks to form Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @TbBd. Furthermore, the zeolitic imidazolate framework\u20108 (ZIF\u20108) was modified on the surface of the Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @TbBd. In addition, Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @TbBd@ZIF\u20108 was used as a magnetic solid\u2010phase extraction (MSPE) adsorbent of typical animal sedatives in pork samples. Mass spectrometry analysis was conducted by electrospray ionization triple\u2010quadrupole mass spectrometry in positive\u2010ion multiple reaction monitoring mode.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      By combining the optimized MSPE approach with high\u2010performance liquid chromatography\/tandem mass spectrometry (HPLC\/MS\/MS), an accurate and sensitive method for the determination of sedatives was developed. The method exhibited good linearity in the range of 0.03\u201370\u2009\u03bcg\/kg with the correlation coefficient (R\n                      <jats:sup>2<\/jats:sup>\n                      ) ranging from 0.9982 to 0.9999, high sensitivity with limits of detection (LODs) ranging from 0.04 to 0.2\u2009\u03bcg\/kg, and high precision with relative standard deviation (RSD) less than 5.5%. The adsorption behaviors of Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @TbBd@ZIF\u20108 towards sedatives were more suitably described by a pseudo\u2010second\u2010order kinetic and Freundlich isotherm model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The proposed MSPE\u2010HPLC\/MS\/MS method was successfully applied to the determination of sedatives in real samples and showed excellent applicability. Several sedatives were detected in the selected meat samples. The developed method was shown to be facile, sensitive and accurate for sedative detection and also showed great prospects for determination of sedatives from other complex samples.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8742","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T06:07:33Z","timestamp":1580710053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Facile preparation of magnetic covalent organic framework\u2013metal organic framework composite materials as effective adsorbents for the extraction and determination of sedatives by high\u2010performance liquid chromatography\/tandem mass spectrometry in meat samples"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-8923","authenticated-orcid":false,"given":"Jichao","family":"Liu","sequence":"first","affiliation":[{"name":"School of Food and Biological Engineering Shaanxi University of Science and Technology  Xi'an 710021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-9750","authenticated-orcid":false,"given":"Guoliang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Shaanxi University of Science and Technology  Xi'an 710021 China"},{"name":"Key Laboratory of Life\u2010Organic Analysis of Shandong Province Qufu Normal University  Qufu 273165 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Yangtze Delta Region Institute of Tsinghua University  Zhejiang 314006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-4480","authenticated-orcid":false,"given":"Yanxin","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Shaanxi University of Science and Technology  Xi'an 710021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Shaanxi University of Science and Technology  Xi'an 710021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongning","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratories of Chemical Safety and Health China National Center for Food Safety Risk Assessment  Beijing 100050 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.01.033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6794"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2015.10.037"},{"key":"e_1_2_6_5_1","unstructured":"Ministry of Agriculture of the People's Republic of China announcement No 235 Ministry of Agriculture;2002."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.05.025"},{"key":"e_1_2_6_7_1","unstructured":"European Council Regulation (EEC) No. 2377\/90\/EC 26 of June 1990 laying down a community procedure for the establishment of maximum residue limit of veterinary medicinal products in foodstuff of animal origin OffEur Commun. 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