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However, traditional methodologies, such as paper spray ionization, have been shown to present low sensitivity in the analysis of illicit drugs from biological matrices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fiber spray ionization mass spectrometry (FSI\u2010MS) was developed using a capillary polypropylene (PP) hollow fiber. Seized samples of drugs, i.e. a tablet, blotter paper, hashish, and cocaine powder, were analyzed. Cocaine was quantified from whole urine by dipping the fiber directly into solution. FSI\u2010MS was tested for the analysis of a sample of urine obtained from a drug abuse suspect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The FSI(+) analysis showed the detection of different types of synthetic drugs in tablet and blotter paper samples, e.g. amphetamine, cathinones, phenethylamines, and opioids, while pure cocaine and different types of coca alkaloids were identified from cocaine powder with good sensitivity and high mass accuracy. The hashish analysis by FSI(\u2212) revealed signals of cannabinoids, cannabinoid acids, and cannabinoid derivatives, detected mainly as [M\u2009\u2212\u2009H]\n                      <jats:sup>\u2212<\/jats:sup>\n                      ions or chlorine adducts [M\u2009+\u2009Cl]\n                      <jats:sup>\u2212<\/jats:sup>\n                      . The quantification of cocaine in whole urine showed good sensitivity and precision with limits of detection and quantification of 5.16 and 17.21\u2009ng\/mL, respectively, linearity above 0.999, and relative standard deviation below 2.71%. The evaluation of seized sample of urine showed the detection of cocaine with relative ion intensity greater than 36%, as well as the metabolites benzoylecgonine and cocaethylene with a relative intensity of 1.4% and 6%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The developed FSI\u2010MS method has the potential to be applied to forensic sample evaluation as well as to determine illicit drugs from biological matrices in toxicological analysis. The use of a capillary PP fiber has advantages as an extractor agent and ionizing substrate, and also the feature of it being dipped directly into the sample, thus preserving the integrity of the sample, which makes this a very promising ambient mass spectrometry method and relevant to forensic chemistry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8747","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T03:00:06Z","timestamp":1581649206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Fiber spray ionization mass spectrometry in forensic chemistry: A screening of drugs of abuse and direct determination of cocaine in urine"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-5804","authenticated-orcid":false,"given":"Jo\u00e3o Francisco 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Bastos","family":"Borges","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Naturais Universidade Federal de S\u00e3o Jo\u00e3o del\u2010Rei  S\u00e3o Jo\u00e3o del\u2010Rei MG 36301\u2010160 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-5443","authenticated-orcid":false,"suffix":"Jr.","given":"Valdemar","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Petrole\u00f4mica e Qu\u00edmica Forense, Departamento de Qu\u00edmica Universidade Federal do Esp\u00edrito Santo  Vit\u00f3ria ES 29075\u2010910 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-9126","authenticated-orcid":false,"given":"Fabr\u00edcio Souza","family":"Peli\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento M\u00e9dico Legal Pol\u00edcia Civil do Esp\u00edrito Santo (PC\u2010ES)  Vit\u00f3ria ES 29045\u2010402 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