{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:15:01Z","timestamp":1772118901941,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["20182\u20102242"],"award-info":[{"award-number":["20182\u20102242"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["XMLX201704"],"award-info":[{"award-number":["XMLX201704"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773891"],"award-info":[{"award-number":["81773891"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2020,5,15]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>\n                      Rhizoma Coptidis (RC) has been used to treat diabetes, pertussis, bacillary dysentery, sore throat, eczema, and aphtha for thousands of years. Alkaloids are the major components in RC, and its curative effect is achieved by oral administration. However, information on its composition\n                      <jats:italic>in vivo<\/jats:italic>\n                      is weak.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, ultra\u2010high\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\/QTOF\u2010MS) was used to analyze the major active components and their metabolites in rat plasma, urine and feces after oral administration of RC extract.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 96 compounds including 8 prototype compounds and 88 metabolites were identified, and hydroxylation, reduction, demethylenation, demethylation, dehydrogenation, sulfation, glucuronidation and methylation were the major metabolic pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study analyzed metabolic processes of the major active components in RC\n                      <jats:italic>in vivo<\/jats:italic>\n                      , which provided important information for its active composition and\n                      <jats:italic>in vivo<\/jats:italic>\n                      mechanism research. Meanwhile, metabolic profile studies on representative compounds provided valuable reference materials to elucidate the full\u2010scale metabolites of RC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8763","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T02:51:27Z","timestamp":1582167087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Metabolic profile of alkaloids in Rhizoma Coptidis in rat plasma, urine and feces after oral administration using ultra\u2010high\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry"],"prefix":"10.1002","volume":"34","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"College of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"},{"name":"Beijing Key Laboratory of Bio\u2010characteristic 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