{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:10Z","timestamp":1772118730235,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Institute of Metrology, China","award":["21-AKYGH1901"],"award-info":[{"award-number":["21-AKYGH1901"]}]},{"name":"The National Key R&D Program of China","award":["2017YFF0205403"],"award-info":[{"award-number":["2017YFF0205403"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>For pharmaceutical quality control, impurities may have unexpected pharmacological or toxicological effects on quality, safety, and efficacy of drugs. Arginine vasopressin (AVP) is an important cyclic peptide drug that is mainly used for the treatment of diabetes insipidus and esophageal varices bleeding. With the advancement made in analytical techniques, liquid chromatography\/high\u2010resolution mass spectrometry (LC\/HRMS) has emerged as a critical technique for the identification and quantification of structurally related peptide impurities in AVP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An LC\/HRMS\/MS\u2010based method using a quadrupole ion trap\u2013Orbitrap mass spectrometer operated in the positive ion electrospray ionization mode was developed for the determination and quantification of structurally related peptide impurities in AVP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Under optimized experimental conditions, three deamidation products, ([Glu\n                      <jats:sup>4<\/jats:sup>\n                      ]AVP, [Asp\n                      <jats:sup>5<\/jats:sup>\n                      ]AVP, and AVP acid), two amino acid deletion impurities (des\u2010Pro\n                      <jats:sup>7<\/jats:sup>\n                      \u2010AVP and des\u2010Gly\n                      <jats:sup>9<\/jats:sup>\n                      \u2010AVP), one amino acid insertion impurity (endo\u2010Gly\n                      <jats:sup>10a<\/jats:sup>\n                      \u2010AVP), one end chain reaction product (\n                      <jats:italic>N<\/jats:italic>\n                      \u2010acetyl\u2010AVP), and one AVP isomer were detected. Subsequent quantification using an external standard method estimated the total mass fraction of all structurally related peptide impurities in the AVP study material to be 30.3\u2009mg\/g with an expanded uncertainty of 3.0\u2009mg\/g (\n                      <jats:italic>k<\/jats:italic>\n                      \u2009=\u20092).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study complements the AVP impurity profile and improves the separation and discovery of other potential impurities in vasopressin analogues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8799","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T18:10:59Z","timestamp":1586023859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impurity identification and quantification for arginine vasopressin by liquid chromatography\/high\u2010resolution mass spectrometry"],"prefix":"10.1002","volume":"34","author":[{"given":"Peize","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Chemical Metrology and Analytical Science National Institute of Metrology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijian","family":"Ye","sequence":"additional","affiliation":[{"name":"College of Chemistry Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-2491","authenticated-orcid":false,"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Chemical Metrology and Analytical Science National Institute of Metrology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Chemical Metrology and Analytical Science National Institute of Metrology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Kan","sequence":"additional","affiliation":[{"name":"Division of Chemical Metrology and Analytical Science National Institute of Metrology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zecheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The Second Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2011"},{"key":"e_1_2_6_3_1","first-page":"147","volume-title":"Advances in Brain Vasopressin","author":"Thibonnier M","year":"1998"},{"issue":"5","key":"e_1_2_6_4_1","first-page":"479","article-title":"Research Progress of vasopressin and its analogues","volume":"31","author":"Liu Q","year":"2017","journal-title":"Chinese Pharm Affairs"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2006.05.011"},{"issue":"6","key":"e_1_2_6_6_1","first-page":"679","article-title":"Current situation and the trend in impurity control of chemical drugs","volume":"40","author":"Hu CQ","year":"2010","journal-title":"Sci China\u2010Chem"},{"key":"e_1_2_6_7_1","unstructured":"Desmopressin. In: European Pharmacopoeia ed.: European Directorate for the Quality of Medicines & Healthcare.European Pharmacopoeia 8.0.2015:2006\u20132007."},{"key":"e_1_2_6_8_1","unstructured":"Vasopressin. 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Available:http:\/\/prospector.ucsf.edu\/prospector\/cgibin\/msform.cgi?form=msproduct. Accessed August 29 2019."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/js980374e"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-017-0202-4"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.8799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.8799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcm.8799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.8799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T09:41:39Z","timestamp":1761471699000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.8799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,4]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6,30]]}},"alternative-id":["10.1002\/rcm.8799"],"URL":"https:\/\/doi.org\/10.1002\/rcm.8799","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/RCM.8799\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.8799\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.8799\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.8799\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.8799\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.8799\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,4]]},"assertion":[{"value":"2020-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8799"}}