{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:14:09Z","timestamp":1772118849829,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2020,10,30]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Succinylcholine has been increasingly used in the theft of animals. Because of the presence of residual levels of succinylcholine in poisoned animals, it is harmful for people to eat foods derived from these animals. Therefore, a method should be immediately established to determine succinylcholine and its metabolite in animal\u2010derived foods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A fast, highly sensitive method, combining solid\u2010phase extraction (SPE) with ultra\u2010performance liquid chromatography\/electrospray ionization tandem mass spectrometry (UPLC\/ESI\u2010MS\/MS), was developed for the determination of succinylcholine and its metabolite in animal\u2010derived foods. The sample was initially extracted with heptafluorobutyric acid and then further cleaned up using an SPE cartridge. Succinylcholine and its metabolite were separated using acetonitrile: 0.1% formic acid in 5\u2009mmol\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ammonium acetate as the mobile phase. Quantitative results were based on positive ion ESI multiple reaction monitoring mode.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results show good linearity over a wide range with correlation coefficients of determination of more than 0.998. Both the limits of detection of succinylcholine and succinylmonocholine are 0.2\u2009\u03bcg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      . The intra\u2010 and inter\u2010day accuracies of the method are in the range 91.4%\u2013104.6%, and the intra\u2010 and inter\u2010day precisions are in the range 2.5%\u20136.6%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This method can be used for the determination of succinylcholine as an illicit drug in animal\u2010derived foods. It was successfully applied to the identification and quantification of succinylcholine and succinylmonocholine in animal\u2010derived foods collected from a local farmers market in Jilin Province of China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.8888","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T01:23:35Z","timestamp":1594603415000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Simultaneous determination of succinylcholine and its metabolite in animal\u2010derived foods by solid\u2010phase extraction combined with ultra\u2010performance liquid chromatography\/mass spectrometry"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-9270","authenticated-orcid":false,"given":"Sijie","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry and Physics Jilin Provincial Center for Disease Control and Prevention  Changchun 130062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics Jilin Provincial Center for Disease Control and Prevention  Changchun 130062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics Jilin Provincial Center for Disease Control and Prevention  Changchun 130062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics Jilin Provincial Center for Disease Control and Prevention  Changchun 130062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics Jilin Provincial Center for Disease Control and Prevention  Changchun 130062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80543-L"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1410"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000512"},{"key":"e_1_2_7_5_1","unstructured":"Office of British Pharmacoeia Commision.BP2013[S].2013; 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