{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:04:38Z","timestamp":1792739078507,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFF0212501"],"award-info":[{"award-number":["2018YFF0212501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21927805"],"award-info":[{"award-number":["21927805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470786"],"award-info":[{"award-number":["31470786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Rationale<\/jats:p>\n                    <jats:p>The rapid identification of small\u2010molecule chiral drugs is challenging due to subtle structural differences. Different enantiomers of chiral drugs may produce inverse biological effects through their different pharmacokinetics. Therefore, it is highly desirable to distinguish the chirality of drug molecules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The chirality of pregabalin was distinguished by studying the ion mobility spectra of the ternary non\u2010covalent complexes formed with cyclodextrins (CDs), pregabalin, and alkali\u2010earth cations using trapped ion mobility spectrometry (TIMS). The ternary non\u2010covalent complex ions were determined by electrospray ionization of mixed solutions. The analyzed sample was simply mixed, without derivatization or sample pretreatment. The relative contents of pregabalin enantiomers were derived using a calibration curve method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ion mobility spectra of several ternary non\u2010covalent complexes formed with \u03b1\u2010, \u03b2\u2010, and \u03b3\u2010CD, pregabalin, and alkali\u2010earth cations were obtained. We compared their ability to distinguish the chirality of pregabalin. The best peak\u2010to\u2010peak resolution (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>p\u2010p<\/jats:sub>\n                      ) was estimated to be 2.20 for [2\u03b2\u2010CD\u2009+\u2009pregabalin\u2009+\u2009Sr]\n                      <jats:sup>2+<\/jats:sup>\n                      , which can be ascribed as baseline separation. The derived relative contents for S\u2010pregabalin were in agreement with the actual contents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A novel and convenient method for discriminating the chirality of the pregabalin molecule by TIMS was developed and optimized. The chirality of pregabalin was recognized by studying the ion mobility spectra of the ternary non\u2010covalent complexes, such as [2\u03b2\u2010CD\u2009+\u2009pregabalin\u2009+\u2009Sr]\n                      <jats:sup>2+<\/jats:sup>\n                      . This TIMS method could also be used to quantify the relative contents of pregabalin enantiomers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.9052","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T08:45:22Z","timestamp":1611132322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enantio\u2010separation of pregabalin by ternary complexation using trapped ion mobility spectrometry"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7945-7884","authenticated-orcid":false,"given":"Liancheng","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Laser Chemistry Institute Fudan University  Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Laser Chemistry Institute Fudan University  Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangling","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Provincial Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo  Zhejiang 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxing","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Provincial Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo  Zhejiang 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoning","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Provincial Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo  Zhejiang 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Laser Chemistry Institute Fudan University  Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Laser Chemistry Institute Fudan University  Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010Fan","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Provincial Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo  Zhejiang 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00474"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083622"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-004-0118-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/385303b0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b05407"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2017.08.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2008.03.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm049762l"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1756"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200704280"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac300437v"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.115804"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14998"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.07.042"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.10.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac001150v"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac020135i"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/b006277o"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6237"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3665933"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC00443D"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.8419"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-013-0690-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12127-016-0213-4"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0608772"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b03661"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr970022c"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA07877B"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja049713y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b02990"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp311671w"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.460375"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.06.071"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP01253E"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b02564"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b04171"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b02827"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.05.026"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12127-017-0227-6"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3560"}],"container-title":["Rapid 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