{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:32:31Z","timestamp":1761492751226,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,1,3]],"date-time":"2003-01-03T00:00:00Z","timestamp":1041552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2003,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tripamide is a drug widely used in clinical practice for the treatment of hypertension and edema. This work evaluated a screening method for Tripamide and its urinary metabolites in human urine, using high\u2010performance liquid chromatography diode\u2010array detection (HPLC\/DAD). Identification of these metabolites was investigated by high\u2010performance liquid chromatography\/electrospray ionization tandem mass spectrometry (HPLC\/ESI\u2010MS\/MS) after dosing with 15 mg Tripamide. Acid hydrolysis showed that Tripamide is conjugated in the body. Two suspected metabolites were detected by HPLC\/DAD. HPLC\/ESI\u2010MS\/MS analysis suggested that these metabolites were probably hydroxylated together with loss of the \u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    group and dehydrogenation. These results will be useful in confirmation methods for Tripamide in doping control. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.913","type":"journal-article","created":{"date-parts":[[2003,2,5]],"date-time":"2003-02-05T20:42:28Z","timestamp":1044477748000},"page":"301-306","source":"Crossref","is-referenced-by-count":3,"title":["Determination of Tripamide in human urine by high\u2010performance liquid chromatography and high\u2010performance liquid chromatography\/electrospray ionization tandem mass spectrometry"],"prefix":"10.1002","volume":"17","author":[{"given":"Yunje","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joungboon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myungsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1,3]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"58","volume-title":"Progress in Drug Metabolism","author":"Bridges JW","year":"1983"},{"key":"e_1_2_5_3_2","first-page":"708","volume-title":"Goodman and Gilman's Pharmacological Basis of Therapeutics","author":"Weiner IM","year":"1990"},{"volume-title":"Diuretics, Physiology, Pharmacology and Clinical Use","year":"1986","author":"Dirks JH","key":"e_1_2_5_4_2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(96)00279-4"},{"key":"e_1_2_5_6_2","unstructured":"International Olympic Committee Medical Commission.International Olympic Charter Against Doping in Sport. 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Institut f\u00fcr Biochemie der Deutschen Sporthochschule: K\u00f6ln1988. 1 private communication."},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1983.133"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)84285-1"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)85332-7"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600640810"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(87)80246-3"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83678-6"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83269-7"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198212000-00008"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)80399-0"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00644-6"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:25:35Z","timestamp":1761492335000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,3]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,2,28]]}},"alternative-id":["10.1002\/rcm.913"],"URL":"https:\/\/doi.org\/10.1002\/rcm.913","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"type":"print","value":"0951-4198"},{"type":"electronic","value":"1097-0231"}],"subject":[],"published":{"date-parts":[[2003,1,3]]}}}