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In the case of biological fluids, hydrolysis followed by solid\u2010phase extraction is required. The solvent in the 96\u2010well plate is evaporated followed by mass spectrometric (MS) analysis with atmospheric pressure chemical ionization. Where applicable, the instrument is operated in data\u2010dependent mode, with a full\u2010scan mass spectrum followed by MS\/MS spectra of the top 10 ions with a total runtime of 0.4\u2009min.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four applications (MAAQ and Tear Gas, twelve rodenticides, seven explosives, and 40 drugs of abuse) are reported in this paper. MAAQ, tear gas, and rodenticides were identified by full\u2010scan, followed by MS\/MS experiments at levels of 125\u2009\u03bcg\/L, 125\u2009\u03bcg\/L, and 500\u2009\u03bcg\/L, respectively. Explosives were all identified at 102\u2009\u03bcg\/L by full\u2010scan experiments. The drugs of abuse were identified by multiple reaction monitoring (MRM) experiments at defined cutoff levels from 2 to 1000\u2009\u03bcg\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Interfacing LDTD with a mass spectrometer allows for rapid screening of a wide range of samples, with either minimal or complex sample preparation. Using a high\u2010resolution mass spectrometer with the combination to perform full\u2010scan and MS\/MS experiments adds a high level of specificity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.9244","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T20:13:26Z","timestamp":1641327206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rapid screening procedures for a variety of complex forensic samples using laser diode thermal desorption (LDTD) coupled to different mass spectrometers"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-7785","authenticated-orcid":false,"given":"Eshwar","family":"Jagerdeo","sequence":"first","affiliation":[{"name":"Federal Bureau of Investigation Laboratory  Quantico VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Auger","sequence":"additional","affiliation":[{"name":"Phytronix Technologies Inc.  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