{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:16Z","timestamp":1772118736085,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>\n                      The dried roots of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Euphorbia kansui<\/jats:italic>\n                      <\/jats:styled-content>\n                      L., known as\n                      <jats:italic>Kansui<\/jats:italic>\n                      , are used to treat ascites and edema in traditional Chinese medicine. However, the toxicity of this herb has seriously restricted its clinical application. A unique vinegar\u2010processing method has been used to reduce its toxicity since the time of ancient China. However, the detoxification mechanism underlying such vinegar processing has not been fully revealed. To find the answer, the process\u2010induced changes in components should be carefully investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a systematic analysis of chemical components in raw and vinegar\u2010processed\n                      <jats:italic>Kansui<\/jats:italic>\n                      using ultrahigh\u2010performance liquid chromatography (UHPLC) diode array detection tandem mass spectrometry and UHPLC high\u2010resolution mass spectrometry. Thirty\u2010one chemical components in raw and vinegar\u2010processed\n                      <jats:italic>Kansui<\/jats:italic>\n                      were found, the chemical structures of 28 components among them were proposed and the process\u2010induced changes in components were then investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A comprehensive conclusion about the process\u2010induced chemical change was drawn. It was found that jatrophane\u2010type diterpenoids decreased markedly after vinegar processing, while ingenane\u2010type diterpenoids were retained during vinegar processing.\n                      <jats:italic>In silico<\/jats:italic>\n                      drug target identification gave hints that jatrophane\u2010type diterpenoids, which decreased markedly during vinegar processing, may have more intense toxicity involving cholinesterase and mitogen\u2010activated protein kinases, while ingenane\u2010type diterpenoids, which were retained during vinegar processing, may have a more intense therapeutic effect involving carbonic anhydrase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The possible detoxification mechanism of vinegar\u2010processed\n                      <jats:italic>Kansui<\/jats:italic>\n                      is presented. The research has significance for the therapeutic\/toxic chemical basis of\n                      <jats:italic>Kansui<\/jats:italic>\n                      . Also, it has significance for drug discovery from terpenoids within the herb.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.9332","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T14:18:46Z","timestamp":1655561926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Detoxification mechanism of vinegar\u2010processed\n                    <i>Kansui<\/i>\n                    revealed by systematic phytochemical analysis using ultrahigh\u2010performance liquid chromatography diode array detection tandem mass spectrometry, ultrahigh\u2010performance liquid chromatography high\u2010resolution mass spectrometry and\n                    <i>in silico<\/i>\n                    drug target identification"],"prefix":"10.1002","volume":"36","author":[{"given":"Lian","family":"Liu","sequence":"first","affiliation":[{"name":"Pharmaceutical Research Institute Wuhan Institute of Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangchun","family":"Li","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Forensic Science Hubei University of Police  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizhong","family":"Lv","sequence":"additional","affiliation":[{"name":"Physical and Chemical Investigation Laboratory Hubei Province Public Security Department  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8600-6566","authenticated-orcid":false,"given":"Haipeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Institute Wuhan Institute of Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen\u2010er","family":"Chen","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Institute Wuhan 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