{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:30Z","timestamp":1786978410583,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>As the public interest in healthcare increases, illegal dietary supplements, foods, and drugs containing unauthorized pharmaceutical ingredients, including nonsteroidal anti\u2010inflammatory drugs (NSAIDs) and acetaminophen, have been identified. Excessive and unintentional consumption is toxic to the gastrointestinal tract, kidneys, and liver; therefore, these pharmaceuticals must be monitored using analytical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A rapid and reliable analysis system involving liquid chromatography\u2013quadrupole orbitrap mass spectrometry (LC\u2010Q\u2010Orbitrap\/MS) and liquid chromatography\u2013tandem mass spectrometry (LC\/MS\/MS) was established and validated to identify and quantify 30 NSAIDs and acetaminophen. In addition, we obtained the MS\n                      <jats:sup>2<\/jats:sup>\n                      spectrum for each component with the proposed structure of the fragment ions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analytical method was applied to 505 samples of illicitly distributed dietary supplements, foods, and pharmaceuticals. Non\u2010steroidal analgesics were detected in 126 samples. Carbamazepine (42.9%) and diclofenac (30.2%) were the most detected components in the samples; other pharmaceutical adulterants were also detected in some cases. Additionally, we present the identification of an unknown component, dexamethasone (799\u2009\u03bcg\/g), using LC\u2010Q\u2010Orbitrap\/MS in a sample containing the unknown component with meloxicam (15.4\u00a0mg\/g).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The developed analysis system, consisting of qualitative analysis using LC\u2010Q\u2010Orbitrap\/MS and quantitative analysis using LC\/MS\/MS, can rapidly and accurately identify and quantify NSAIDs and acetaminophen while also identifying non\u2010analytical components.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.9462","type":"journal-article","created":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T20:05:47Z","timestamp":1671998747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Liquid chromatography\u2013quadrupole orbitrap and liquid chromatography\u2013tandem mass spectrometry system for rapid identification and quantitation of thirty nonsteroidal anti\u2010inflammatory drugs and acetaminophen in illegal products"],"prefix":"10.1002","volume":"37","author":[{"given":"Hyoung\u2010Joon","family":"Park","sequence":"first","affiliation":[{"name":"Center for Advanced Analysis National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Chungcheongbuk\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-9009","authenticated-orcid":false,"given":"Hyeon Joo","family":"Ham","sequence":"additional","affiliation":[{"name":"Center for Advanced Analysis National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Chungcheongbuk\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Ji","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Advanced Analysis National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Chungcheongbuk\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyeong","family":"Seo","sequence":"additional","affiliation":[{"name":"Center for Advanced Analysis National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Chungcheongbuk\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Advanced Analysis National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Chungcheongbuk\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for 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