{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:15:11Z","timestamp":1772118911123,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["93PTE\/2022"],"award-info":[{"award-number":["93PTE\/2022"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2024,2,28]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Glycol\u2010based antifreeze liquids, commonly composed of ethylene glycol or propylene glycol, have important uses in automotive cooling, but they should be handled with care due to their toxicity. Ethylene glycol is highly toxic to humans and animals. A fast, accurate, precise, and robust method was developed for the simultaneous quantification of seven most important glycols and their isomers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Glycols were analyzed from diluted sample solution of coolants using gas chromatography coupled with mass spectrometry (GC\u2013MC) in single ion monitoring mode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The method was developed and validated for seven individual glycols (ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, and tripropylene glycol). Limits of detection (1\u20132\u00a0\u03bcg\/mL) and limits of quantification (10\u00a0\u03bcg\/mL) obtained were appropriate. The present method was applied for the determination of glycols in 10 different antifreeze liquids commercially available on the Romanian market, proving to be reliable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A method that requires only a two\u2010step dilution of antifreeze samples combined with direct liquid injection GC\u2013MS was validated for the simultaneous quantification of seven glycols (and their isomers) in 10 different types of antifreeze liquids. The results obtained in the validation procedure proved that the GC\u2013MS method is sensitive and precise for the quantification of glycols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.9686","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T04:29:37Z","timestamp":1703219377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Simultaneous quantification of seven glycols in antifreeze liquids using direct liquid injection gas chromatography coupled with mass spectrometry"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1763-327X","authenticated-orcid":false,"given":"George Madalin","family":"Danila","sequence":"first","affiliation":[{"name":"Cromatec Plus SRL, Research Center for Instrumental Analysis SCIENT  Tancabesti Ilfov Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaiella","family":"Cretu","sequence":"additional","affiliation":[{"name":"National Research and Development Institute of Gas Turbines COMOTI  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Puscasu","sequence":"additional","affiliation":[{"name":"National Research and Development Institute of Gas Turbines COMOTI  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2023.102279"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104684\u20108691\u20109_25"},{"key":"e_1_2_8_4_1","unstructured":"GiesenY FriedrichC BreuerD et al.Glycols\u2014method for the determination of diethylene glycol ethylene glycol and propylene glycol in workplace air using gas chromatography [air monitoring methods 2018]. The MAK\u2010Collection for Occupational Health and Safety."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/26.5.280"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193\u20101801\u20102\u2010203"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.9734\/ACSJ\/2013\/3675"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","unstructured":"ASTM Standard E202\u201018.Standard test methods for analysis of ethylene glycols and propylene glycols ASTM International.2019. doi:10.1520\/E0202\u201018 www.astm.org","DOI":"10.1520\/E0202"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.9686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T09:27:05Z","timestamp":1761470825000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.9686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2,28]]}},"alternative-id":["10.1002\/rcm.9686"],"URL":"https:\/\/doi.org\/10.1002\/rcm.9686","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/RCM.9686\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.9686\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.9686\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.9686\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]},"assertion":[{"value":"2023-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9686"}}