{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:14:50Z","timestamp":1772118890401,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870314"],"award-info":[{"award-number":["31870314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Erigeron breviscapus<\/jats:italic>\n                      (EB) and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Erigeron multiradiatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      (EM) are the two species of the genus\n                      <jats:italic>Erigeron<\/jats:italic>\n                      (Asteraceae) with extremely close genetic relationships. They were used as the same \u201cmeiduoluomi\u201d for the treatment of plague and epidemics in traditional Tibetan medicine. But in traditional Chinese medicine, only EB is used for treatment of cerebrovascular obstruction, hemiplegia due to stroke, coronary artery obstruction, chest congestion, and angina pectoris. These two\n                      <jats:italic>Erigeron<\/jats:italic>\n                      species show different effects in different traditional medicine systems. Therefore, analyzing the chemical compositions of two species will not only enhance comprehension of their medicinal properties but also foster the advancement and exploration of novel applications. However, to date, there has been no comprehensive and detailed investigation comparing the constituents of EB and EM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A methodology for rapid identification of chemical profiles from two\n                      <jats:italic>Erigeron<\/jats:italic>\n                      species was devised through the integration of ultra\u2010high\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight tandem mass spectrometry (UHPLC\u2010QTOF\u2010MS\/MS) and multivariate statistical analysis. Additionally, a UHPLC\u2010photo\u2010diode array (PDA) method was established to precisely quantify of 11 components.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 58 constituents comprising flavonoids, phenolic acids, saponin, and long chain fatty acids were elucidated. Thirteen compounds were identified as potential differentiators in chemical profiles among the two\n                      <jats:italic>Erigeron<\/jats:italic>\n                      species. For quantitative assessment, 11 bioactive compounds were simultaneously quantified across 49 batches of\n                      <jats:italic>Erigeron<\/jats:italic>\n                      species samples utilizing UHPLC\u2010PDA with wavelengths of 325, 254, and 266\u2009nm. The method demonstrated excellent precision, linearity, accuracy, repeatability, stability, and recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings from this study will serve as a reference for quality control, functional activity exploration, and improved clinical application based on the ingredient profiles of the two species. Furthermore, this inaugural investigation into the ingredient profiles of these two species will enhance the potential and optimal utilization of both EB and EM resources.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.9929","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:29:09Z","timestamp":1730766549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Two\n                    <i>Erigeron<\/i>\n                    species comparison based on their ingredient profile by UPLC\u2010PDA\u2010QTOF\u2010MS\/MS and discriminant analysis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-5466","authenticated-orcid":false,"given":"Jianguang","family":"Zhang","sequence":"first","affiliation":[{"name":"Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Southwest Minzu University  Chengdu China"},{"name":"Qinzhou Provincial Health School  Qinzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Southwest Minzu University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiansang","family":"Wulu","sequence":"additional","affiliation":[{"name":"Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Southwest Minzu University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfang","family":"Jin","sequence":"additional","affiliation":[{"name":"Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Southwest Minzu University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Southwest Minzu University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Southwest Minzu University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.656335"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3321\/j.issn:1672\u20109072.2000.03.018"},{"issue":"5","key":"e_1_2_9_4_1","first-page":"360","article-title":"Study on the structure and activity of new phenolic acid compounds from Erigeron breviscapus","volume":"36","author":"Zhang W","year":"2001","journal-title":"Acta Pharm Sin"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.07.046"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.13375\/j.cnki.wcjps.2017.03.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500646"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.128.1293"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1004\u2010275X.2024.03.10"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7501\/j.issn.0253\u20102670.2019.02.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12040775"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.128.805"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.06.048"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2022.2132374"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2023.2189477"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2902"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.9317"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.9029"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10762"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2023.101031"},{"key":"e_1_2_9_21_1","unstructured":"Flora of China Editorial Committee.Flora of China2010(Chinese Edition). China: Beijing."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.7501\/j.issn.0253\u20102670.2022.15.026"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23081850"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337\u2010010\u20101703\u2010x"},{"key":"e_1_2_9_25_1","unstructured":"ZhangW KongD LiH et al.Research on the active ingredients ofErigeron breviscapusand development of new drugs. The 4th China New Doctor of Medicine Forum.1999; 4."},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.01.020"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.08.037"},{"issue":"2","key":"e_1_2_9_28_1","first-page":"143","article-title":"Study on the chemical components of Erigeron breviscapus (I)","volume":"21","author":"Zhang W","year":"2000","journal-title":"Acad J Second MilMed Univ"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1004\u2010275X.2004.05.008"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132932"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ra00046c"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201045017\u20102"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.05.007"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7580731"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9115"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7961940"},{"issue":"10","key":"e_1_2_9_37_1","first-page":"1006","article-title":"Caffeoylquinic acid derivatives extract of Erigeron multiradiatus alleviated acute myocardial ischemia reperfusion injury in rats through inhibiting NF\u2010kappaB and JNK activations","volume":"30","author":"Zhang Z","year":"2016","journal-title":"Chin J Pharmacol Toxicol"},{"key":"e_1_2_9_38_1","unstructured":"Chinese Pharmacopoeia Commission.Chinese Pharmacopoeia2020(Chinese Edition). China: Beijing."}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.9929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:53:01Z","timestamp":1761490381000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.9929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,15]]}},"alternative-id":["10.1002\/rcm.9929"],"URL":"https:\/\/doi.org\/10.1002\/rcm.9929","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/RCM.9929\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.9929\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.9929\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.9929\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.9929\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/RCM.9929\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]},"assertion":[{"value":"2024-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9929"}}