{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:45:01Z","timestamp":1792496701129,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00AR071508"],"award-info":[{"award-number":["R00AR071508"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR072714"],"award-info":[{"award-number":["R01AR072714"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA016058"],"award-info":[{"award-number":["P30 CA016058"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA180057"],"award-info":[{"award-number":["R01CA180057"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JCSM Rapid Communications"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer patients who exhibit cachexia lose weight and have low treatment tolerance and poor outcomes compared with cancer patients without weight loss. Despite the clear increased risk for patients, diagnosing cachexia still often relies on self\u2010reported weight loss. A reliable biomarker to identify patients with cancer cachexia would be a valuable tool to improve clinical decision making and identification of patients at risk of adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Targeted metabolomics, which included panels of amino acids, tricarboxylic acids, fatty acids, acylcarnitines, and sphingolipids, were conducted on plasma samples from patients with confirmed pancreatic ductal adenocarcinoma (PDAC) with and without cachexia and control patients without cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010\/group, equally divided by sex). Additional patient samples were analysed (total\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a095), and receiver operating characteristic (ROC) analyses were performed to establish if any metabolite could effectively serve as a biomarker of cachexia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Targeted profiling revealed that cachectic patients had decreased circulating levels of three sphingolipids compared with either non\u2010cachectic PDAC patients or patients without cancer. The ratio of C18\u2010ceramide to C24\u2010ceramide (C18:C24) outperformed a number of other previously proposed biomarkers of cachexia (area under ROC\u00a0=\u00a00.810). It was notable that some biomarkers, including C18:C24, were only altered in cachectic males.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings identify C18:C24 as a potentially new biomarker of PDAC\u2010induced cachexia that also highlight a previously unappreciated sexual dimorphism in cancer cachexia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rco2.68","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T02:30:13Z","timestamp":1655778613000},"page":"254-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Identification of circulating plasma ceramides as a potential sexually dimorphic biomarker of pancreatic cancer\u2010induced cachexia"],"prefix":"10.1002","volume":"5","author":[{"given":"Jeffery M.","family":"Chakedis","sequence":"first","affiliation":[{"name":"Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Division of Surgical Oncology The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of General Surgery, The Permanente Medical Group Kaiser Permanente Walnut Creek Medical Center  Walnut Creek CA 94596 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Dillhoff","sequence":"additional","affiliation":[{"name":"Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Division of Surgical Oncology The Ohio State University  Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl R.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Division of Surgical Oncology The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Surgery West Virginia University  Morgantown WV 26506 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyani V.","family":"Rajasekera","sequence":"additional","affiliation":[{"name":"Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Radiation Oncology The Ohio State University  Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Evans","sequence":"additional","affiliation":[{"name":"Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Division of Trauma, Critical Care, and Burn The Ohio State University  Columbus OH 43210 USA"},{"name":"OhioHealth Trauma Services  Columbus OH 43215 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Radiation Oncology The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Radiation Oncology City of Hope National Medical Center  Duarte CA 91010 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-6609","authenticated-orcid":false,"given":"Denis C.","family":"Guttridge","sequence":"additional","affiliation":[{"name":"Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Cancer Biology and Genetics The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Pediatrics Medical University of South Carolina  Charleston SC 29425 USA"},{"name":"Hollings Cancer Center Medical University of South Carolina  Charleston SC 29425 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-0950","authenticated-orcid":false,"given":"Erin E.","family":"Talbert","sequence":"additional","affiliation":[{"name":"Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Cancer Biology and Genetics The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Pediatrics Medical University of South Carolina  Charleston SC 29425 USA"},{"name":"Hollings Cancer Center Medical University of South Carolina  Charleston SC 29425 USA"},{"name":"Department of Health and Human Physiology and Holden Comprehensive Cancer Center University of Iowa  Iowa City IA 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_9_3_1","first-page":"3347","article-title":"Limited impact of total parenteral nutrition on nutritional status during treatment for small cell lung cancer","volume":"45","author":"Evans WK","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607189013004406"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)10090-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2014.000976"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.05.028"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0505-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000898"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2014.11.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2017.11.10"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801375"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980011003193"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-1-11"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2018.11.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12251"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113259"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101594"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12246"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-010-0232-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.147751"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12270"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24940"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom3030435"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw148"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12033"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4318"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/28.1.12"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3122-y"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12761"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12273"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00628-w"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312432"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0686"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12626"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2017.11.001"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2020.2308"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bodyim.2008.11.004"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(01)00008-6"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P035808"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2640"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-019-1544-z"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010538"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6216"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.02.005"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M008011"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.86"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-142"}],"container-title":["JCSM Rapid Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rco2.68","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rco2.68","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rco2.68","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T16:15:14Z","timestamp":1692807314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rco2.68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/rco2.68"],"URL":"https:\/\/doi.org\/10.1002\/rco2.68","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.01.20111492","asserted-by":"object"}]},"ISSN":["2617-1619","2617-1619"],"issn-type":[{"value":"2617-1619","type":"print"},{"value":"2617-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,20]]},"assertion":[{"value":"2021-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}