{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:09:57Z","timestamp":1788570597697,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":98,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AA024726"],"award-info":[{"award-number":["R01AA024726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JCSM Communications"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Impaired muscle function is frequent in cirrhosis and potentially participates in liver disease progression. Data from non\u2010cirrhotic patients with steatotic liver disease (SLD) are lacking. Our aims were to determine if muscle function was impaired in a non\u2010cirrhotic cohort of patients with SLD and if the SLD subtype and severity were associated with impaired muscle function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with SLD and controls were prospectively recruited. Liver disease was assessed by imaging, vibration\u2010controlled transient elastography and non\u2010invasive tests. Muscle function was assessed by the liver frailty index (LFI) and isokinetic dynamometer. Diet and physical activity habits were recorded using dedicated questionnaires to measure the energetic balance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One\u2010hundred and fifty patients with non\u2010cirrhotic SLD (75 patients with metabolic dysfunction\u2010associated steatotic liver disease [MASLD] and 75 patients with alcohol\u2010related liver disease [ALD]) and 30 non\u2010SLD controls were prospectively recruited. The LFI negatively correlated to lower limb muscle strength assessed by isokinetic dynamometer in all participant groups (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.82 in the control group;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.69 in the pooled SLD group\u2014\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Both SLD groups showed muscle strength impairment assessed by the LFI compared to age\u2010 and gender\u2010matched controls. In multivariate analysis, the presence of SLD was associated with impaired muscle function independently of age, BMI and energetic balance, with a higher risk related to ALD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with SLD already show impaired muscle function compared to controls independently of age, gender and energetic balance. Taken together, our data support a potential disruption of the liver\u2013muscle axis already occurring in SLD prior to cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT06514300<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rco2.70012","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:20:13Z","timestamp":1759904413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Non\u2010Cirrhotic Steatotic Liver Disease is Associated With Impaired Muscle Function: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"8","author":[{"given":"Guillaume","family":"Henin","sequence":"first","affiliation":[{"name":"Laboratoire de gastro\u2010ent\u00e9rologie (GAEN) Institut de recherche exp\u00e9rimentale et clinique (IREC), UCLouvain  Brussels Belgium"},{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Goffaux","sequence":"additional","affiliation":[{"name":"Laboratoire de gastro\u2010ent\u00e9rologie (GAEN) Institut de recherche exp\u00e9rimentale et clinique (IREC), UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e9","family":"Declerck","sequence":"additional","affiliation":[{"name":"Laboratoire de gastro\u2010ent\u00e9rologie (GAEN) Institut de recherche exp\u00e9rimentale et clinique (IREC), UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Andr\u00e9\u2010Dumont","sequence":"additional","affiliation":[{"name":"Laboratoire de gastro\u2010ent\u00e9rologie (GAEN) Institut de recherche exp\u00e9rimentale et clinique (IREC), UCLouvain  Brussels Belgium"},{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Pendeville","sequence":"additional","affiliation":[{"name":"Service de kin\u00e9sith\u00e9rapie et ergoth\u00e9rapie Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Valet","sequence":"additional","affiliation":[{"name":"Laboratoire de pathologie neuro\u2010musculo\u2010squelettique (NMSK) Institut de recherche exp\u00e9rimentale et clinique (IREC), UCLouvain  Brussels Belgium"},{"name":"Service de m\u00e9decine physique et r\u00e9adaptation Grand H\u00f4pital de Charleroi  Charleroi Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Laboratoire de pathologie neuro\u2010musculo\u2010squelettique (NMSK) Institut de recherche exp\u00e9rimentale et clinique (IREC), UCLouvain  Brussels Belgium"},{"name":"Service de m\u00e9decine physique et r\u00e9adaptation Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Dahlqvist","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Loumaye","sequence":"additional","affiliation":[{"name":"Service d'endocrinologie et diab\u00e9tologie Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schnabl","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Diego  La Jolla CA USA"},{"name":"Department of Medicine VA San Diego Healthcare System  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"St\u00e4rkel","sequence":"additional","affiliation":[{"name":"Laboratoire de gastro\u2010ent\u00e9rologie (GAEN) Institut de recherche exp\u00e9rimentale et clinique (IREC), UCLouvain  Brussels Belgium"},{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-9314","authenticated-orcid":false,"given":"Nicolas","family":"Lanthier","sequence":"additional","affiliation":[{"name":"Laboratoire de gastro\u2010ent\u00e9rologie (GAEN) Institut de recherche exp\u00e9rimentale et clinique (IREC), UCLouvain  Brussels Belgium"},{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.774030"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15938"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-023-01113-z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100963"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i40.5807"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.51821\/85.4.10899"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14358"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.025"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29219"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1353406"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198908020-00003"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2023.05.020"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111902"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2021-000861"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1330221"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1101892"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00256-7"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.35946\/arcr.v38.2.05"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2036205"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.04.043"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.10.007"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30124-9"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.06.013"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.03.029"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2024.102428"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25449"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2014-100432"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2013.09.018"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001119"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.07.003"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00427-8"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100197"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01811-7"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11081305"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15947"}],"container-title":["JCSM Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rco2.70012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T12:04:50Z","timestamp":1766405090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rco2.70012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/rco2.70012"],"URL":"https:\/\/doi.org\/10.1002\/rco2.70012","archive":["Portico"],"relation":{},"ISSN":["2996-1394","2996-1394"],"issn-type":[{"value":"2996-1394","type":"print"},{"value":"2996-1394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70012"}}