{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:09Z","timestamp":1753870149673,"version":"3.41.2"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurosarcoidosis is a rare complication of sarcoidosis and unusually presents as optic neuritis. We present the case of a 51\u2010year\u2010old man who complained of right vision loss. Brain magnetic resonance imaging showed asymmetrical enlargement of the right optic nerve. Chest computed tomography detected mediastinal and hilar lymphadenopathy. There were cutaneous nodules on the back. Biopsy of the mediastinal lymph node by endobronchial ultrasound\u2010guided transbronchial needle aspiration and the skin showed noncaseating granulomas consistent with sarcoidosis. Serum angiotensin\u2010converting enzyme level was elevated (34.2\u00a0IU\/L) (normal: 8.3\u201321.4\u00a0IU\/L). Based on these findings, he was diagnosed as neurosarcoidosis with optic neuritis. He was started on 1000\u2010mg\/day methylprednisolone intravenously for 3\u2009days, followed by oral 50\u2010mg\/day prednisolone, which was gradually tapered for 8\u2009weeks. Thereafter, the skin nodules and lymphadenopathy decreased and the right vision partially improved. Based on this rare case, sarcoidosis should be considered as a differential diagnosis in cases of optic neuritis.<\/jats:p>","DOI":"10.1002\/rcr2.1110","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T08:55:45Z","timestamp":1677056145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sarcoidosis presenting as optic neuritis with vision loss"],"prefix":"10.1002","volume":"11","author":[{"given":"Ryosuke","family":"Kataoka","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6197-5176","authenticated-orcid":false,"given":"Yoshiro","family":"Kai","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Neurology Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-0975","authenticated-orcid":false,"given":"Hiromasa","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-9191","authenticated-orcid":false,"given":"Shigeo","family":"Muro","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2021.1940740"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"228","article-title":"Optic nerve sarcoidosis: MR findings","volume":"13","author":"Engelken JD","year":"1992","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.808"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0959-9673.2003.00365.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.36141\/svdld.v34i2.5410"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1602382"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.1110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T12:32:42Z","timestamp":1692275562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/rcr2.1110"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1110","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2023,2,22]]},"assertion":[{"value":"2022-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01110"}}