{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:08Z","timestamp":1753870148836,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Portopulmonary hypertension is an uncommon disease associated with high morbidity and mortality, so its early diagnosis and treatment are essential. We report here the case of a 57\u2010year\u2010old man with portopulmonary hypertension caused by chronic hepatosplenic schistosomiasis and also liver cirrhosis due to hepatitis C and alcoholism. As well as treating both diseases, portopulmonary hypertension was successfully managed with tadalafil and macitentan as maintenance therapy. This case reminds clinicians that pulmonary hypertension can be multifactorial, a good diagnosis and a multidisciplinary treatment can lead to improved prognosis.<\/jats:p>","DOI":"10.1002\/rcr2.1114","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T06:23:42Z","timestamp":1679034222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Portopulmonary hypertension: Success with combined medical treatment"],"prefix":"10.1002","volume":"11","author":[{"given":"Mar\u00eda","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Hospital Universitario de San Juan  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-5884","authenticated-orcid":false,"given":"Violeta","family":"Esteban","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital Universitario de San Juan  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital General Universitario de Alicante  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Boira","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital Universitario de San Juan  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Wickmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario de San Juan  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 N.","family":"Sancho\u2010Chust","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital Universitario de San Juan  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Gil","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital General Universitario de Alicante  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.569413"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30091-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0089-2019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.07.027"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.1114","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T11:14:39Z","timestamp":1692702879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/rcr2.1114"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1114","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2023,3,16]]},"assertion":[{"value":"2022-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01114"}}