{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:10Z","timestamp":1753870150171,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune checkpoint inhibitors (ICIs) unleash potent anti\u2010tumour responses but with frequent off\u2010target immune\u2010mediated adverse events (irAE). ICIs can induce a spectrum of rheumatologic manifestations including inflammatory arthritis, Sj\u00f6gren's syndrome, scleroderma and systemic lupus erythematosus. Here, we describe a case of antisynthetase syndrome associated interstitial lung disease (ILD) following dual Programmed Cell Death 1 and Cytotoxic T Lymphocyte\u2010Associated Protein 4 checkpoint inhibition in a patient with metastatic melanoma. Initial treatment course was complicated by a number of irAEs including pneumonitis, colitis and thyroiditis. Suspicion of an underlying systemic rheumatic disease was heightened by the severe, relapsing and fibrosing nature of the interstitial pneumonitis. A diagnosis of amyopathic antisynthetase syndrome was made upon detection of circulating aminoacyl\u2010tRNA synthetase (anti\u2010EJ) autoantibodies. Intensification of induction immunosuppression followed by maintenance mycophenolate, prednisone and monthly intravenous immunoglobulin achieved long\u2010term disease control. Detection of de novo ICI\u2010induced inflammatory myositis ILD requires a high index of suspicion and carries important prognostic and treatment implications.<\/jats:p>","DOI":"10.1002\/rcr2.1115","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T12:20:44Z","timestamp":1678710044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010synthetase syndrome associated interstitial lung disease after combination dual immune checkpoint inhibition"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0653-0286","authenticated-orcid":false,"given":"Peter T.","family":"Bell","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sunshine Coast University Hospital  Sunshine Coast Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Beaton","sequence":"additional","affiliation":[{"name":"Department of Immunology Sunshine Coast University Hospital  Sunshine Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Terrill","sequence":"additional","affiliation":[{"name":"Department of Immunology Sunshine Coast University Hospital  Sunshine Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gillis","sequence":"additional","affiliation":[{"name":"Department of Immunology Sunshine Coast University Hospital  Sunshine Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Goddard","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sunshine Coast University Hospital  Sunshine Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1038\/s41571-019-0218-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1183\/16000617.00002015"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/S2213-2600(18)30172-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1183\/16000617.0012-2019"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1136\/jitc-2020-001731"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1016\/j.autrev.2012.06.006"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1378\/chest.10-0180"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1590\/S1806-37132011000100015"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1136\/annrheumdis-2019-215031"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.1115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T11:14:26Z","timestamp":1692702866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/rcr2.1115"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1115","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"assertion":[{"value":"2022-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01115"}}