{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:12Z","timestamp":1753870152842,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Krukenberg tumours are unusual metastatic tumours of the ovary with primary tumours from the stomach, breast and gastrointestinal malignancies. Krukenberg tumour from pulmonary malignancy represents an extremely rare situation. This is an elaboration of a case of young women with Krukenberg tumour rising from lung adenocarcinoma. A 38\u2010year\u2010old woman presented with progressive abdominal distention for the past 2\u2010years. Computed tomography (CT) of thorax, abdomen and pelvis revealed a huge ovarian mass with left lung nodules and left\u2010sided pleural effusion. A detailed immunohistochemical staining on pleural fluid cytology confirmed the diagnosis of metastatic adenocarcinoma of lung origin. She underwent doublet platinum chemotherapy as molecular testing for oncogenic mutation was negative. The patient responded well to chemotherapy with a significant reduction in ovarian tumour size. Early identification of the primary source of Krukenberg tumour is paramount to avoid invasive diagnostic surgical intervention for ovarian metastasis.<\/jats:p>","DOI":"10.1002\/rcr2.1133","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T03:10:31Z","timestamp":1680664231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Krukenberg tumour as the initial manifestation of lung adenocarcinoma"],"prefix":"10.1002","volume":"11","author":[{"given":"Guat Yee","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hospital Selayang  Batu Caves Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-2254","authenticated-orcid":false,"given":"Yen Shen","family":"Wong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University Teknologi MARA (UiTM)  Sg Buloh Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahrah","family":"Tawil","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Selayang  Batu Caves Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roqiah Fatmawati","family":"Abdul Kadir","sequence":"additional","affiliation":[{"name":"Department of Radiology University Teknologi MARA (UiTM)  Sg Buloh Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamalai","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Hospital Selayang  Batu Caves Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisya","family":"Natasya Musa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University Teknologi MARA (UiTM)  Sg Buloh Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"479","article-title":"Krukenberg tumors of the ovary: a clinicopathologic analysis of 112 cases","volume":"39","author":"Yakushiji M","year":"1987","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2015.58.1.32"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.12.039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000190787.85024.cb"},{"volume-title":"StatPearls [Internet]","year":"2021","author":"Aziz M","key":"e_1_2_9_6_1"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"101","article-title":"Data to the clinical manifestation of the Krukenberg tumour","volume":"37","author":"Cs\u00f6m\u00f6r S","year":"1998","journal-title":"Acta Chir Hung"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950615)75:12<2844::AID-CNCR2820751209>3.0.CO;2-#"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3182612643"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126780.10029.f0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800791241"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v9.i1.13"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068227"},{"issue":"8","key":"e_1_2_9_14_1","first-page":"819","article-title":"Acute abdomen secondary to torsion of Krukenberg tumour","volume":"61","author":"Bibi S","year":"2011","journal-title":"JPMA J Pak Med Assoc"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:39:13Z","timestamp":1692693553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,4]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/rcr2.1133"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1133","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2023,4,4]]},"assertion":[{"value":"2023-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01133"}}