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A 62\u2010year\u2010old man using high\u2010dose inhaled corticosteroid visited our hospital because of poorly\u2010controlled asthma. He had eosinophilia in peripheral blood and sputum, and high levels of fraction of exhaled nitric oxide. Therefore, he was treated with mepolizumab for severe asthma. Mepolizumab treatment resulted in significantly improved pulmonary function and reduced frequencies of asthma exacerbations. Because of his good asthma control, mepolizumab treatment was discontinued after 3\u2009years. Since discontinuing mepolizumab, his asthma control has remained without exacerbation. Previous studies suggest that mepolizumab should be continued to sustain clinical benefits. However, cases of long\u2010term controlled asthma have not been reported after mepolizumab withdrawal, and our case may be instructive.<\/jats:p>","DOI":"10.1002\/rcr2.1158","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T09:28:10Z","timestamp":1683797290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Severe asthma remaining well\u2010controlled after mepolizumab discontinuation: A case report and literature review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5167-8579","authenticated-orcid":false,"given":"Takahiro","family":"Matsuyama","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima 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