{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:08:15Z","timestamp":1764133695746,"version":"3.41.2"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic eosinophilic pneumonia (CEP) is an eosinophilic lung disease. Treatment for CEP includes corticosteroids; however, CEP often recurs. A 53\u2010year\u2010old woman was referred to our hospital because of poorly controlled asthma. She was treated with combination of moderate\u2010dose inhaled corticosteroid (ICS), a long\u2010acting \u03b22\u2010agonist (LABA), and betamethasone\/dexchlorpheniramine. She was switched to single\u2010inhaler triple therapy, after which her asthma control improved; thus, betamethasone\/dexchlorpheniramine was discontinued. Ten weeks later, she was diagnosed with CEP due to marked eosinophilia and pulmonary eosinophilic infiltrates. Oral corticosteroid treatment was initiated, symptoms improved, and peripheral blood eosinophilia decreased with improved infiltrative shadows. Remission induction therapy was initiated with benralizumab combined with corticosteroid therapy. Eosinophilia and inflammatory responses decreased. After 7\u2009months, corticosteroid was discontinued, and she was treated with benralizumab alone. She remained in remission for 4\u2009months. This case suggests that benralizumab may be useful as a remission induction therapy in patients with CEP.<\/jats:p>","DOI":"10.1002\/rcr2.1279","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T07:10:31Z","timestamp":1705561831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful discontinuation of corticosteroids through remission induction therapy with benralizumab for chronic eosinophilic pneumonia"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6197-5176","authenticated-orcid":false,"given":"Yoshiro","family":"Kai","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-2475","authenticated-orcid":false,"given":"Eriko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Minami\u2010Nara General Medical Center  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-9191","authenticated-orcid":false,"given":"Shigeo","family":"Muro","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10040638"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i18.6105"},{"key":"e_1_2_9_4_1","article-title":"Rapid and sustained effects of a single dose of benralizumab on chronic eosinophilic pneumonia","volume":"30","author":"Izumo T","year":"2020","journal-title":"Respir Med Case Rep"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.02.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.826790"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2022.08.008"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T11:18:58Z","timestamp":1706267938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/rcr2.1279"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1279","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01279"}}