{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:22Z","timestamp":1753870162062,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two cases of intractable chronic cough improved significantly with humidified high flow therapy (HHFT). A 59\u2010year\u2010old woman with Primary Sjogren's disease and interstitial lung disease, was trialled on a Fisher and Paykel myAIRVO\u2122 system. She reported sustained benefits of uninterrupted sleep and increased socialization with tapering use of HHFT. A 67\u2010year\u2010old woman with idiopathic pulmonary fibrosis also benefited from the use of myAIRVO\u2122. She had relentless cough with minimal movement, and nocturnal cough causing fragmented sleep. Her cough subsided considerably with continuous HHFT, but recurred without. Both patients reported significant reductions in the cough visual analogue scale. The mechanisms by which HHFT improve intractable cough may include reducing airway dryness, inhibition of neutrophil inflammation and mucus obstruction, and splinting of the airways. HHFT significantly improved cough and health\u2010related quality of life in two patients with interstitial lung disease. Further research is warranted to explore the role of domiciliary HHFT.<\/jats:p>","DOI":"10.1002\/rcr2.1323","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:54:45Z","timestamp":1710572085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel therapy for intractable chronic cough"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2512-0705","authenticated-orcid":false,"given":"Matthew","family":"Bricknell","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-6293","authenticated-orcid":false,"given":"Chris Zi\u2010Fan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Smallwood","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Alfred Hospital  Melbourne Victoria Australia"},{"name":"Respiratory Research @ Alfred, Central Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Austin Health  Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534666211049743"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23916"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.01996.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0224-2020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072663"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T08:39:24Z","timestamp":1711528764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/rcr2.1323"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1323","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2024-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01323"}}