{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:22Z","timestamp":1753870162991,"version":"3.41.2"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019609","name":"National Center for PTSD, U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX000105"],"award-info":[{"award-number":["CX000105"]}],"id":[{"id":"10.13039\/100019609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL149719"],"award-info":[{"award-number":["R01HL149719"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Birt\u2013Hogg\u2013Dub\u00e9 syndrome (BHD) typically does not manifest airway obstruction despite the presence of multiple lung cysts. However, the long\u2010term effects of cigarette smoking on lung function among individuals with BHD are unknown. We report a case of a smoking individual diagnosed with BHD syndrome complicated by spontaneous pneumothorax and severe airway obstruction. The patient presented with chronic dyspnea and productive cough. Further work\u2010up revealed severe obstructive airflow limitation, and multiple lung cysts in both lungs, accompanied centrilobular emphysematous changes. Genetic testing confirmed a heterozygous deletion of exons 6\u20138 in the <jats:italic>folliculin<\/jats:italic> gene, confirming the diagnosis of BHD.<\/jats:p>","DOI":"10.1002\/rcr2.1327","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T12:58:40Z","timestamp":1711198720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of Birt\u2013Hogg\u2013Dub\u00e9 syndrome associated with severe airway obstruction in a 62\u2010year\u2010old female smoker"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5818-3028","authenticated-orcid":false,"given":"Kiyoshi","family":"Uemasu","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nyunoya","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Medical Specialty Service Line Veterans Affairs Pittsburgh Healthcare System  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0042-2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00076209"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1483OC"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ad.2011.07.009","article-title":"Actualizaci\u00f3n en el s\u00edndrome Birt\u2013Hogg\u2013Dub\u00e9","volume":"103","author":"L\u00f3pez V","year":"2012","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0656-7"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Cigarette smoking is a secondary cause of folliculin loss","author":"Li X","year":"2022","journal-title":"Thorax"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T08:39:32Z","timestamp":1711528772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/rcr2.1327"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1327","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01327"}}