{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:30:45Z","timestamp":1769927445404,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) is a revolutionary tool for the diagnosis and staging of mediastinal disorders. Nevertheless, its diagnostic capability is reduced in certain disorders such as lymphoproliferative diseases. EBUS\u2010guided transbronchial mediastinal cryobiopsy (EBUS\u2010TBMC) is a novel technique that can provide larger samples with preserved tissue architecture, with an acceptable safety profile. In this case report, we present a middle\u2010aged gentleman with a huge anterior mediastinal mass and bilateral mediastinal and hilar lymphadenopathy. He underwent EBUS\u2010TBNA with rapid on\u2010site evaluation (ROSE) followed by EBUS\u2010TBMC, all under general anaesthesia. Histopathological analysis showed discordance between EBUS\u2010TBNA and EBUS\u2010TBMC in which only TBMC samples provided adequate tissue to attain a diagnosis of primary mediastinal large B\u2010cell lymphoma. This case report reinforced the diagnostic role of EBUS\u2010TBMC in the diagnosis of lymphoproliferative diseases.<\/jats:p>","DOI":"10.1002\/rcr2.1342","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T01:53:26Z","timestamp":1712195606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The utility of endobronchial ultrasound\u2010guided transbronchial mediastinal cryobiopsy (<scp>EBUS\u2010TBMC<\/scp>) for the diagnosis of mediastinal lymphoma"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-4189","authenticated-orcid":false,"given":"Nai\u2010Chien","family":"Huan","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Queen Elizabeth Hospital  Kota Kinabalu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Lun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department 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Hospital  Kota Kinabalu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahziela","family":"Yunus","sequence":"additional","affiliation":[{"name":"Department of Pathology Queen Elizabeth Hospital  Kota Kinabalu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.180762"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/med-23-34"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/med-21-2"},{"key":"e_1_2_8_5_1","article-title":"EBUS\u2010guided cryobiopsy in the diagnosis of thoracic disorders","volume":"23","author":"Poletti 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