{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:07:15Z","timestamp":1785514035940,"version":"3.56.0"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 70\u2010year\u2010old immunocompetent male with a history of insomnia presented with pneumonia and bacteremia caused by <jats:italic>Bacillus subtilis<\/jats:italic>. The patient took benzodiazepines and regularly consumed alcohol and natto (fermented soybeans). Initial antibiotic treatment was not effective, and bronchoalveolar lavage was performed. Bronchoalveolar lavage fluid (BALF) analysis revealed an increased lymphocytes fraction, and <jats:italic>B. subtilis<\/jats:italic> was detected in the BALF. Whole\u2010genome sequencing confirmed the congruence of the genetic sequences between the strain in the blood culture of the patient, BALF, and strain isolated from the consumed natto, confirming <jats:italic>B. subtilis<\/jats:italic> subsp<jats:italic>. natto<\/jats:italic> as the causative pathogen of pneumonia and bacteremia. Vancomycin followed by levofloxacin and systemic corticosteroid were used to treat the condition. This case highlights community\u2010acquired pneumonia and bacteremia caused by <jats:italic>B. subtilis<\/jats:italic> subsp<jats:italic>. natto<\/jats:italic>, particularly in individuals who consume natto.<\/jats:p>","DOI":"10.1002\/rcr2.1384","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:04:52Z","timestamp":1715673892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of community\u2010acquired pneumonia caused by <i>Bacillus subtilis<\/i> subsp. <i>natto<\/i> in an immunocompetent patient"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-2697","authenticated-orcid":false,"given":"Tetsuo","family":"Tani","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Tokyo Saiseikai Central Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-6592","authenticated-orcid":false,"given":"Tomohiro","family":"Takehara","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Tokyo Saiseikai Central Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-1436","authenticated-orcid":false,"given":"Kota","family":"Ishioka","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Tokyo Saiseikai Central Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Yoshifuji","sequence":"additional","affiliation":[{"name":"Department of infectious diseases Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases Toho University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-4203","authenticated-orcid":false,"given":"Saeko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Tokyo Saiseikai Central Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2022.05.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2808.211567"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2910.230084"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.1.325-326.1998"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02091-17"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0768-22"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2116777"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:15:38Z","timestamp":1716941738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/rcr2.1384"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1384","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2024-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01384"}}